Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 41565..42157 Replicon plasmid pCFSAN001297_02
Accession NZ_CP019199
Organism Salmonella enterica subsp. enterica serovar Muenster str. 0315

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag SEEM0315_RS25235 Protein ID WP_000513532.1
Coordinates 41565..41813 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag SEEM0315_RS25240 Protein ID WP_000681609.1
Coordinates 41810..42157 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEM0315_RS25175 36589..37185 + 597 WP_000125164.1 hypothetical protein -
SEEM0315_RS26630 37203..37487 - 285 WP_001162371.1 hypothetical protein -
SEEM0315_RS25185 37561..38226 - 666 WP_000532148.1 P-loop NTPase -
SEEM0315_RS25195 38825..39148 + 324 WP_000427402.1 hypothetical protein -
SEEM0315_RS25200 39189..39398 + 210 WP_000866037.1 hypothetical protein -
SEEM0315_RS25205 39496..39720 + 225 WP_000814384.1 hypothetical protein -
SEEM0315_RS25210 39772..40032 + 261 WP_000702246.1 hypothetical protein -
SEEM0315_RS25215 40022..40273 + 252 WP_001132407.1 transcriptional regulator -
SEEM0315_RS25230 40822..41100 + 279 WP_000545937.1 hypothetical protein -
SEEM0315_RS25235 41565..41813 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
SEEM0315_RS25240 41810..42157 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SEEM0315_RS25245 42245..42427 - 183 WP_001428470.1 hypothetical protein -
SEEM0315_RS25250 42929..43228 + 300 WP_000466320.1 type II toxin-antitoxin system HicB family antitoxin -
SEEM0315_RS25255 43488..43814 - 327 WP_000206697.1 hypothetical protein -
SEEM0315_RS25260 43816..44175 - 360 WP_024147837.1 hypothetical protein -
SEEM0315_RS25265 44276..44983 - 708 WP_000108794.1 hypothetical protein -
SEEM0315_RS25270 44985..45737 - 753 WP_000797966.1 conjugal transfer protein TraL -
SEEM0315_RS25275 45755..46156 - 402 WP_021575837.1 hypothetical protein -
SEEM0315_RS25280 46525..46866 + 342 WP_000730722.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59062 59062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T71826 WP_000513532.1 NZ_CP019199:41565-41813 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T71826 NZ_CP019199:41565-41813 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT71826 WP_000681609.1 NZ_CP019199:41810-42157 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT71826 NZ_CP019199:41810-42157 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References