Detailed information of TA system TA071825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 39772..40273
• Replicon: plasmid pCFSAN001297_02
• Accession: NZ_CP019199
• Organism: Salmonella enterica subsp. enterica serovar Muenster str. 0315

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: Q9F571
• Locus tag: SEEM0315_RS25210
• Protein ID: WP_000702246.1
• Coordinates: 39772..40032 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: SEEM0315_RS25215
• Protein ID: WP_001132407.1
• Coordinates: 40022..40273 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEM0315_RS25170	36278..36439	+	162	WP_001434039.1	type I toxin-antitoxin system Hok family toxin	-
SEEM0315_RS25175	36589..37185	+	597	WP_000125164.1	hypothetical protein	-
SEEM0315_RS26630	37203..37487	-	285	WP_001162371.1	hypothetical protein	-
SEEM0315_RS25185	37561..38226	-	666	WP_000532148.1	P-loop NTPase	-
SEEM0315_RS25195	38825..39148	+	324	WP_000427402.1	hypothetical protein	-
SEEM0315_RS25200	39189..39398	+	210	WP_000866037.1	hypothetical protein	-
SEEM0315_RS25205	39496..39720	+	225	WP_000814384.1	hypothetical protein	-
SEEM0315_RS25210	39772..40032	+	261	WP_000702246.1	hypothetical protein	Toxin
SEEM0315_RS25215	40022..40273	+	252	WP_001132407.1	transcriptional regulator	Antitoxin
SEEM0315_RS25230	40822..41100	+	279	WP_000545937.1	hypothetical protein	-
SEEM0315_RS25235	41565..41813	+	249	WP_000513532.1	type II toxin-antitoxin system HicA family toxin	-
SEEM0315_RS25240	41810..42157	+	348	WP_000681609.1	type II toxin-antitoxin system HicB family antitoxin	-
SEEM0315_RS25245	42245..42427	-	183	WP_001428470.1	hypothetical protein	-
SEEM0315_RS25250	42929..43228	+	300	WP_000466320.1	type II toxin-antitoxin system HicB family antitoxin	-
SEEM0315_RS25255	43488..43814	-	327	WP_000206697.1	hypothetical protein	-
SEEM0315_RS25260	43816..44175	-	360	WP_024147837.1	hypothetical protein	-
SEEM0315_RS25265	44276..44983	-	708	WP_000108794.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59062	59062

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 11169.16 Da
• Isoelectric Point: 12.7344

>T71825 WP_000702246.1 NZ_CP019199:39772-40032 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKK

Nucleotide

• Length: 261 bp

>T71825 NZ_CP019199:39772-40032 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT71825 WP_001132407.1 NZ_CP019199:40022-40273 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT71825 NZ_CP019199:40022-40273 [Salmonella enterica subsp. enterica serovar Muenster str. 0315]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A3E1XBA7