Detailed information of TA system TA071823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 163754..164279
• Replicon: plasmid pATCCBAA1673_01
• Accession: NZ_CP019190
• Organism: Salmonella enterica subsp. enterica serovar Poona str. ATCC BAA-1673

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: SEEP1673_RS26305
• Protein ID: WP_023213233.1
• Coordinates: 163974..164279 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A730EJ33
• Locus tag: SEEP1673_RS26300
• Protein ID: WP_023213232.1
• Coordinates: 163754..163972 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEP1673_RS26260	158910..159446	-	537	WP_023213765.1	type 1 fimbrial protein	-
SEEP1673_RS26265	159766..160422	-	657	WP_071646393.1	tyrosine-type recombinase/integrase	-
SEEP1673_RS26270	160595..161671	-	1077	Protein_177	ISKra4 family transposase	-
SEEP1673_RS27000	161687..161893	-	207	Protein_178	plasmid pRiA4b ORF-3 family protein	-
SEEP1673_RS26280	162359..162775	-	417	WP_023213230.1	type II toxin-antitoxin system VapC family toxin	-
SEEP1673_RS26285	162772..163002	-	231	WP_023213231.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
SEEP1673_RS26300	163754..163972	+	219	WP_023213232.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SEEP1673_RS26305	163974..164279	+	306	WP_023213233.1	type II toxin-antitoxin system toxin CcdB	Toxin
SEEP1673_RS26310	164281..164562	+	282	WP_023213234.1	hypothetical protein	-
SEEP1673_RS26315	164659..165093	+	435	WP_023213235.1	hypothetical protein	-
SEEP1673_RS26320	165090..165872	+	783	WP_023213236.1	site-specific integrase	-
SEEP1673_RS26325	166016..166747	-	732	Protein_186	Rpn family recombination-promoting nuclease/putative transposase	-
SEEP1673_RS26330	166848..168107	+	1260	WP_023213263.1	tyrosine-type recombinase/integrase	-
SEEP1673_RS26335	168101..169015	+	915	WP_023213264.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..186451	186451

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T71823 WP_023213233.1 NZ_CP019190:163974-164279 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T71823 NZ_CP019190:163974-164279 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT71823 WP_023213232.1 NZ_CP019190:163754-163972 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT71823 NZ_CP019190:163754-163972 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A730EJ33