Detailed information of TA system TA071818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 95419..95972
• Replicon: plasmid pATCCBAA1673_01
• Accession: NZ_CP019190
• Organism: Salmonella enterica subsp. enterica serovar Poona str. ATCC BAA-1673

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: SEEP1673_RS25935
• Protein ID: WP_023214121.1
• Coordinates: 95658..95972 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A730HTS6
• Locus tag: SEEP1673_RS25930
• Protein ID: WP_023214120.1
• Coordinates: 95419..95655 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEP1673_RS25895	90649..91482	+	834	WP_023214169.1	sel1 repeat family protein	-
SEEP1673_RS25900	91543..92817	+	1275	WP_023214168.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
SEEP1673_RS25905	92839..93351	+	513	WP_080092427.1	CaiF/GrlA family transcriptional regulator	-
SEEP1673_RS25910	93348..93962	+	615	WP_071645911.1	LuxR C-terminal-related transcriptional regulator	-
SEEP1673_RS25915	93973..94476	+	504	WP_023214117.1	CaiF/GrlA family transcriptional regulator	-
SEEP1673_RS26825	94502..94669	+	168	WP_157934966.1	hypothetical protein	-
SEEP1673_RS25930	95419..95655	+	237	WP_023214120.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
SEEP1673_RS25935	95658..95972	+	315	WP_023214121.1	CcdB family protein	Toxin
SEEP1673_RS25940	96189..96968	+	780	WP_080092426.1	tyrosine-type recombinase/integrase	-
SEEP1673_RS25945	97293..97766	+	474	WP_102035459.1	CaiF/GrlA family transcriptional regulator	-
SEEP1673_RS25950	97763..98392	+	630	WP_079932843.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..186451	186451

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 13476.30 Da
• Isoelectric Point: 12.8170

>T71818 WP_023214121.1 NZ_CP019190:95658-95972 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 315 bp

>T71818 NZ_CP019190:95658-95972 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 10143.77 Da
• Isoelectric Point: 12.6921

>AT71818 WP_023214120.1 NZ_CP019190:95419-95655 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 237 bp

>AT71818 NZ_CP019190:95419-95655 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A730HTS6