Detailed information of TA system TA071817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 48167..48726
• Replicon: plasmid pATCCBAA1673_01
• Accession: NZ_CP019190
• Organism: Salmonella enterica subsp. enterica serovar Poona str. ATCC BAA-1673

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5Y3Y4U8
• Locus tag: SEEP1673_RS25685
• Protein ID: WP_023213428.1
• Coordinates: 48451..48726 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SEEP1673_RS25680
• Protein ID: WP_023213429.1
• Coordinates: 48167..48451 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEP1673_RS25630	44023..44172	+	150	WP_023213432.1	type I toxin-antitoxin system Hok family toxin	-
SEEP1673_RS25635	44442..44720	+	279	WP_023213431.1	replication regulatory protein RepA	-
SEEP1673_RS25645	44940..45017	+	78	WP_042835575.1	RepA leader peptide Tap	-
SEEP1673_RS25650	44998..45876	+	879	WP_077911924.1	incFII family plasmid replication initiator RepA	-
SEEP1673_RS25665	47023..47130	+	108	Protein_55	XRE family transcriptional regulator	-
SEEP1673_RS25670	47149..47412	+	264	WP_001089475.1	hypothetical protein	-
SEEP1673_RS25675	47402..47701	+	300	WP_001528606.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SEEP1673_RS25680	48167..48451	+	285	WP_023213429.1	ribbon-helix-helix protein, CopG family	Antitoxin
SEEP1673_RS25685	48451..48726	+	276	WP_023213428.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SEEP1673_RS25690	48769..49038	-	270	WP_024160590.1	hypothetical protein	-
SEEP1673_RS25695	49034..49411	-	378	Protein_61	recombinase family protein	-
SEEP1673_RS25700	49678..50082	-	405	Protein_62	recombinase family protein	-
SEEP1673_RS25705	50179..50769	+	591	WP_023213424.1	plasmid pRiA4b ORF-3 family protein	-
SEEP1673_RS25710	50906..51013	+	108	Protein_64	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..186451	186451

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T71817 WP_023213428.1 NZ_CP019190:48451-48726 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T71817 NZ_CP019190:48451-48726 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT71817 WP_023213429.1 NZ_CP019190:48167-48451 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT71817 NZ_CP019190:48167-48451 [Salmonella enterica subsp. enterica serovar Poona str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A5Y3Y4U8