Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 52041..52696 Replicon plasmid pATCC39184
Accession NZ_CP019180
Organism Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag BWD35_RS24925 Protein ID WP_000812999.1
Coordinates 52268..52696 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag BWD35_RS24920 Protein ID WP_001261283.1
Coordinates 52041..52271 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWD35_RS24880 47579..47915 - 337 Protein_60 hypothetical protein -
BWD35_RS24885 47909..48418 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
BWD35_RS24890 48422..49135 - 714 WP_000545756.1 EAL domain-containing protein -
BWD35_RS24895 49144..49926 - 783 WP_000082169.1 site-specific integrase -
BWD35_RS24900 49961..50482 - 522 WP_000198608.1 hypothetical protein -
BWD35_RS24905 50479..50769 - 291 WP_001266176.1 hypothetical protein -
BWD35_RS24910 50771..51076 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
BWD35_RS24915 51078..51296 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
BWD35_RS24920 52041..52271 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BWD35_RS24925 52268..52696 + 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin Toxin
BWD35_RS24940 53266..54114 - 849 WP_000175391.1 SdiA-regulated domain-containing protein -
BWD35_RS25790 54140..54301 - 162 WP_001816720.1 hypothetical protein -
BWD35_RS24945 54562..54774 - 213 WP_000063794.1 hypothetical protein -
BWD35_RS24950 54847..55431 - 585 WP_001575501.1 hypothetical protein -
BWD35_RS24955 55556..56269 - 714 WP_000801115.1 hypothetical protein -
BWD35_RS24960 56269..56544 - 276 WP_001020576.1 hypothetical protein -
BWD35_RS24965 56531..57295 - 765 WP_000827659.1 K88 minor fimbrial subunit faeI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74560 74560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 18346.91 Da        Isoelectric Point: 12.9522

>T71814 WP_000812999.1 NZ_CP019180:52268-52696 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 429 bp

>T71814 NZ_CP019180:52268-52696 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT71814 WP_001261283.1 NZ_CP019180:52041-52271 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT71814 NZ_CP019180:52041-52271 [Salmonella enterica subsp. enterica serovar Dublin str. ATCC 39184]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RF18

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References