Detailed information of TA system TA071810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 74168..74823
• Replicon: plasmid pCFSAN024229
• Accession: NZ_CP019175
• Organism: Salmonella enterica subsp. enterica serovar Give strain CFSAN024229

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A0A2A6D4W4
• Locus tag: LM70_RS25355
• Protein ID: WP_023972453.1
• Coordinates: 74395..74823 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A2A6D545
• Locus tag: LM70_RS25350
• Protein ID: WP_023972452.1
• Coordinates: 74168..74398 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM70_RS25320	70410..70985	-	576	WP_031233190.1	PIN domain-containing protein	-
LM70_RS25325	70985..71446	-	462	WP_023972447.1	helix-turn-helix domain-containing protein	-
LM70_RS25335	71755..72531	-	777	Protein_81	phage integrase family protein	-
LM70_RS25340	72528..73235	-	708	WP_023972450.1	hypothetical protein	-
LM70_RS25665	73279..73593	-	315	WP_139148288.1	hypothetical protein	-
LM70_RS25350	74168..74398	+	231	WP_023972452.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LM70_RS25355	74395..74823	+	429	WP_023972453.1	PIN domain-containing protein	Toxin
LM70_RS25360	74864..75742	-	879	WP_023972454.1	restriction endonuclease	-
LM70_RS25365	76003..76617	+	615	WP_023972455.1	DNA-binding protein	-
LM70_RS25375	76994..77506	+	513	WP_023972457.1	hypothetical protein	-
LM70_RS25380	77531..77821	+	291	WP_023972458.1	hypothetical protein	-
LM70_RS25385	77818..78081	+	264	WP_023972459.1	hypothetical protein	-
LM70_RS25390	78163..78714	-	552	WP_023972460.1	N-acetyltransferase	-
LM70_RS25395	78725..78967	-	243	WP_023972461.1	hypothetical protein	-
LM70_RS25405	79181..79549	+	369	Protein_93	DUF302 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94727	94727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-137)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 18346.91 Da
• Isoelectric Point: 12.9522

>T71810 WP_023972453.1 NZ_CP019175:74395-74823 [Salmonella enterica subsp. enterica serovar Give]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 429 bp

>T71810 NZ_CP019175:74395-74823 [Salmonella enterica subsp. enterica serovar Give]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9887.42 Da
• Isoelectric Point: 12.6808

>AT71810 WP_023972452.1 NZ_CP019175:74168-74398 [Salmonella enterica subsp. enterica serovar Give]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 231 bp

>AT71810 NZ_CP019175:74168-74398 [Salmonella enterica subsp. enterica serovar Give]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A2A6D4W4

Antitoxin

• AlphaFold DB: A0A2A6D545