Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 6286444..6287123 Replicon chromosome
Accession NZ_CP019171
Organism MAG: Delftia acidovorans isolate ANG1

Toxin (Protein)


Gene name vapC Uniprot ID A9C106
Locus tag AO536_RS28515 Protein ID WP_012207638.1
Coordinates 6286444..6286869 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A9C107
Locus tag AO536_RS28520 Protein ID WP_012207639.1
Coordinates 6286866..6287123 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO536_RS28490 6281870..6282136 + 267 WP_225971011.1 hypothetical protein -
AO536_RS28495 6282078..6282590 - 513 WP_012207634.1 MgtC/SapB family protein -
AO536_RS28500 6282706..6284163 - 1458 WP_012207635.1 chloride channel protein -
AO536_RS28505 6284321..6285214 - 894 WP_043782971.1 LysR family transcriptional regulator -
AO536_RS28510 6285356..6286405 + 1050 WP_012207637.1 NAD(P)-dependent alcohol dehydrogenase -
AO536_RS28515 6286444..6286869 - 426 WP_012207638.1 type II toxin-antitoxin system VapC family toxin Toxin
AO536_RS28520 6286866..6287123 - 258 WP_012207639.1 plasmid stability protein stbC Antitoxin
AO536_RS28525 6287227..6288024 - 798 WP_012207640.1 precorrin-6A synthase (deacetylating) -
AO536_RS28530 6288021..6288899 - 879 WP_012207641.1 precorrin-4 C(11)-methyltransferase -
AO536_RS28535 6288896..6289393 - 498 WP_012207642.1 cobalamin biosynthesis protein -
AO536_RS28540 6289390..6290592 - 1203 WP_012207643.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
AO536_RS28545 6290591..6291385 + 795 WP_043782972.1 cobalt-precorrin-6A reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15291.58 Da        Isoelectric Point: 6.2293

>T71808 WP_012207638.1 NZ_CP019171:c6286869-6286444 [Delftia acidovorans]
MIVVDTNVISELWRLAPDSRVLAWMDAQAIETLHLSAVTVAELRYGIAAMPEGRRRTIYQERLEHEVLPAFAGRVLAFDL
DAAKAYADLMASAKTQGRAIAKADGYIAATAMAHGLVVATRDTRPFEAGGLQTINPWTAAP

Download         Length: 426 bp

>T71808 NZ_CP019171:c6286869-6286444 [Delftia acidovorans]
ATGATCGTTGTCGATACCAACGTCATTTCGGAACTCTGGAGGCTTGCGCCCGACTCCAGAGTGCTTGCCTGGATGGACGC
CCAGGCCATTGAAACGCTGCATCTGTCTGCCGTCACCGTGGCAGAACTGCGCTACGGCATTGCAGCGATGCCTGAGGGAA
GGCGCCGCACCATCTACCAGGAGCGACTGGAGCATGAGGTTCTGCCGGCCTTCGCCGGCCGTGTCCTGGCCTTTGACCTG
GACGCGGCAAAGGCCTATGCCGATCTGATGGCGAGCGCGAAGACGCAGGGCAGGGCCATCGCCAAGGCCGATGGCTATAT
AGCGGCCACTGCCATGGCGCATGGGCTGGTGGTGGCAACGCGCGACACCCGTCCGTTCGAGGCCGGTGGGCTGCAGACCA
TCAATCCCTGGACGGCAGCGCCCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9403.56 Da        Isoelectric Point: 6.2300

>AT71808 WP_012207639.1 NZ_CP019171:c6287123-6286866 [Delftia acidovorans]
MANVTVRNLPDAVHRALRVRAAHHGRSTEAEIRDILEAAVRPEERVRLGSMLASIAREAGGLTDSEAEGFNRLRDRAPAE
PMDFE

Download         Length: 258 bp

>AT71808 NZ_CP019171:c6287123-6286866 [Delftia acidovorans]
ATGGCCAATGTGACTGTGAGAAACCTGCCCGATGCCGTGCACCGGGCCTTGCGGGTACGCGCTGCCCACCATGGCCGCAG
TACGGAGGCGGAAATCCGCGACATTCTGGAAGCCGCCGTCCGGCCGGAAGAGCGTGTCAGGCTCGGCTCCATGCTGGCGT
CCATTGCCCGCGAGGCAGGAGGACTGACCGACTCCGAAGCCGAGGGCTTCAACCGCCTGCGCGACAGGGCGCCAGCCGAG
CCCATGGACTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9C106

Antitoxin

Source ID Structure
AlphaFold DB A9C107

References