Detailed information of TA system TA071807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 6262112..6262692
• Replicon: chromosome
• Accession: NZ_CP019171
• Organism: MAG: Delftia acidovorans isolate ANG1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A9C0Y2
• Locus tag: AO536_RS28390
• Protein ID: WP_012207614.1
• Coordinates: 6262312..6262692 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A9C0Y1
• Locus tag: AO536_RS28385
• Protein ID: WP_012207613.1
• Coordinates: 6262112..6262315 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AO536_RS28375	6259343..6261019	-	1677	WP_012207611.1	VRR-NUC domain-containing protein	-
AO536_RS28380	6261129..6261941	-	813	WP_012207612.1	glucose 1-dehydrogenase	-
AO536_RS28385	6262112..6262315	+	204	WP_012207613.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
AO536_RS28390	6262312..6262692	+	381	WP_012207614.1	type II toxin-antitoxin system VapC family toxin	Toxin
AO536_RS28395	6262742..6264619	-	1878	WP_012207615.1	CocE/NonD family hydrolase	-
AO536_RS28400	6264631..6265608	-	978	WP_043782962.1	tripartite tricarboxylate transporter substrate binding protein	-
AO536_RS28405	6265645..6266661	-	1017	WP_012207617.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-114)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13931.34 Da
• Isoelectric Point: 8.5635

>T71807 WP_012207614.1 NZ_CP019171:6262312-6262692 [Delftia acidovorans]
MNPVLVDTSVWIDHFRQGNPHLVQLLQQDMTLMHPLVLGELACGTPPARARTLADLQRLKPARQASMREVMALIEREQLF
GLGCGLVDMTLLASALMSSGASLWSLDKRLHALAQRFGIAYRPTGQ

Nucleotide

• Length: 381 bp

>T71807 NZ_CP019171:6262312-6262692 [Delftia acidovorans]
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGTGCAGCTGCTGCA
GCAAGACATGACGCTCATGCACCCCCTGGTGCTGGGCGAACTGGCCTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CAGACCTTCAACGGCTCAAGCCTGCCCGGCAGGCCAGCATGCGCGAAGTGATGGCCTTGATAGAGCGCGAGCAGCTCTTT
GGTCTGGGCTGCGGCCTGGTGGACATGACGCTCCTGGCCTCGGCACTCATGTCTTCAGGCGCCAGCCTGTGGTCGCTGGA
CAAGCGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTACCGTCCCACAGGCCAGTAG

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7485.58 Da
• Isoelectric Point: 4.5702

>AT71807 WP_012207613.1 NZ_CP019171:6262112-6262315 [Delftia acidovorans]
MRTTVTIDDALYEEALELAEPEMDKADLFREAVKTFVRVQAAKRLAALGGSAPDMREIPRRPQGIEP

Nucleotide

• Length: 204 bp

>AT71807 NZ_CP019171:6262112-6262315 [Delftia acidovorans]
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCGTCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGCCTGGCCGCGCTGGGAGGCAGCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA

Structures

Toxin

• AlphaFold DB: A9C0Y2

Antitoxin

• AlphaFold DB: A9C0Y1