Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3958022..3958695 Replicon chromosome
Accession NZ_CP019171
Organism MAG: Delftia acidovorans isolate ANG1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AO536_RS18045 Protein ID WP_232244039.1
Coordinates 3958022..3958420 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AO536_RS18050 Protein ID WP_012205584.1
Coordinates 3958429..3958695 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO536_RS18030 3953066..3954139 + 1074 WP_192812290.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
AO536_RS18035 3954196..3955728 + 1533 WP_012205581.1 acyl-CoA carboxylase subunit beta -
AO536_RS18040 3955940..3957988 + 2049 WP_012205582.1 acetyl-CoA carboxylase biotin carboxylase subunit -
AO536_RS18045 3958022..3958420 - 399 WP_232244039.1 type II toxin-antitoxin system VapC family toxin Toxin
AO536_RS18050 3958429..3958695 - 267 WP_012205584.1 DNA-binding protein Antitoxin
AO536_RS18055 3958935..3959906 + 972 WP_012205585.1 chemotaxis protein -
AO536_RS18060 3959943..3961037 - 1095 WP_012205586.1 LacI family DNA-binding transcriptional regulator -
AO536_RS18065 3961194..3961781 + 588 WP_012205587.1 gluconokinase -
AO536_RS18070 3961800..3962306 + 507 WP_012205588.1 TRAP transporter small permease -
AO536_RS18075 3962319..3963599 + 1281 WP_012205589.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 7.3858

>T71806 WP_232244039.1 NZ_CP019171:c3958420-3958022 [Delftia acidovorans]
MLDTNAASEAIRGNPLFDARLQALAPGQWCVSAVTCSELRYGIARRPEAVRLARIVEAFLHITAILPWDARAANQHGQLR
AYLRAQGSPIGDFDEMIAAHALALDAILVTDNVRHFERISGLRIENWLRQGH

Download         Length: 399 bp

>T71806 NZ_CP019171:c3958420-3958022 [Delftia acidovorans]
ATGCTGGACACCAATGCCGCCAGCGAAGCCATCCGGGGCAATCCCTTGTTTGATGCGCGCTTGCAAGCCCTCGCACCAGG
GCAGTGGTGCGTTAGTGCAGTGACCTGTTCCGAGCTGCGCTATGGAATTGCCCGGCGGCCCGAGGCGGTACGGCTGGCAC
GGATCGTGGAGGCGTTCCTGCACATCACCGCCATCCTGCCCTGGGACGCCAGGGCGGCCAACCAGCATGGTCAGTTGCGT
GCTTATCTGCGTGCCCAGGGCTCGCCGATTGGAGACTTCGACGAAATGATCGCCGCACATGCGCTGGCCCTGGACGCGAT
CCTGGTCACAGACAATGTGCGGCATTTCGAACGCATTTCCGGGCTCAGGATCGAAAACTGGCTGCGCCAGGGGCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10097.25 Da        Isoelectric Point: 4.6388

>AT71806 WP_012205584.1 NZ_CP019171:c3958695-3958429 [Delftia acidovorans]
MPPVTAQLFATDGVQAVKLPAEFRFEDRAEVYIRRDENTGDVILSTIPRADWSEFMRLRHQLGHAAESALPVRQQGSEQR
DPFQGWEE

Download         Length: 267 bp

>AT71806 NZ_CP019171:c3958695-3958429 [Delftia acidovorans]
ATGCCACCCGTTACCGCCCAACTTTTCGCCACCGATGGCGTTCAAGCCGTAAAGCTGCCTGCCGAGTTTCGCTTCGAAGA
TCGAGCCGAGGTGTATATCCGCCGCGATGAAAACACCGGAGACGTCATTCTTTCGACCATTCCTCGCGCGGACTGGAGTG
AATTCATGCGGCTGCGCCACCAGCTGGGGCATGCGGCCGAGTCGGCCCTCCCCGTGCGCCAACAGGGCAGCGAGCAACGC
GATCCCTTCCAAGGTTGGGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References