Detailed information of TA system TA071805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1875405..1875994
• Replicon: chromosome
• Accession: NZ_CP019171
• Organism: MAG: Delftia acidovorans isolate ANG1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A9BSX0
• Locus tag: AO536_RS08525
• Protein ID: WP_012203615.1
• Coordinates: 1875698..1875994 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A9BSW9
• Locus tag: AO536_RS08520
• Protein ID: WP_012203614.1
• Coordinates: 1875405..1875701 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AO536_RS08505	1871269..1871883	+	615	WP_012203611.1	SCO family protein	-
AO536_RS08510	1872045..1873622	+	1578	WP_012203612.1	PAS domain-containing methyl-accepting chemotaxis protein	-
AO536_RS08515	1873640..1875376	+	1737	WP_225971059.1	EAL domain-containing protein	-
AO536_RS08520	1875405..1875701	-	297	WP_012203614.1	putative addiction module antidote protein	Antitoxin
AO536_RS08525	1875698..1875994	-	297	WP_012203615.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AO536_RS08530	1876042..1876725	-	684	WP_043780967.1	Crp/Fnr family transcriptional regulator	-
AO536_RS08535	1876961..1877938	-	978	WP_012203617.1	hypothetical protein	-
AO536_RS08540	1877938..1879890	-	1953	WP_012203618.1	StlD/DarB family beta-ketosynthase	-
AO536_RS08545	1879906..1880841	-	936	WP_012203619.1	fatty acid desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11232.01 Da
• Isoelectric Point: 10.0308

>T71805 WP_012203615.1 NZ_CP019171:c1875994-1875698 [Delftia acidovorans]
MYSVIETEAFADWVDSIRDIPTRIRLRRRLGKAMRGNLGDVKSVGEGLWEMREFFGPGWRMYYIQRDHVLIVMLGGGDKS
SQAQDIAAARAMAREIKL

Nucleotide

• Length: 297 bp

>T71805 NZ_CP019171:c1875994-1875698 [Delftia acidovorans]
ATGTACAGCGTCATCGAAACCGAGGCGTTTGCTGATTGGGTAGACAGCATTCGTGACATACCAACTCGTATCCGCCTGCG
TCGTCGCCTGGGCAAAGCCATGCGCGGAAACCTGGGAGACGTGAAATCCGTTGGCGAGGGCCTATGGGAGATGCGCGAGT
TTTTTGGGCCAGGTTGGCGCATGTACTACATCCAACGCGATCATGTTCTGATCGTGATGCTTGGCGGCGGAGACAAGTCC
AGCCAGGCACAGGACATTGCTGCGGCCAGGGCGATGGCCAGGGAGATCAAGCTATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10768.22 Da
• Isoelectric Point: 4.6151

>AT71805 WP_012203614.1 NZ_CP019171:c1875701-1875405 [Delftia acidovorans]
MSNIKMRPFDMANYLGTEEEIVEYLRQALEDNDPAELAAALGDIARARGMTQLARDTGLSRESLYKSLSGERAPSSETLF
KVIQAMGFRLTIAPAASQ

Nucleotide

• Length: 297 bp

>AT71805 NZ_CP019171:c1875701-1875405 [Delftia acidovorans]
ATGAGCAACATCAAGATGCGGCCATTCGACATGGCCAACTACCTCGGCACCGAAGAGGAAATCGTGGAGTACCTGCGCCA
GGCGCTGGAAGACAACGATCCGGCCGAACTGGCTGCGGCGCTGGGCGACATCGCACGCGCGCGCGGCATGACTCAGCTCG
CTCGCGACACCGGACTTTCTCGGGAAAGCCTCTACAAAAGCCTGTCTGGCGAACGGGCGCCCAGTTCCGAGACGCTGTTC
AAGGTGATTCAGGCCATGGGCTTCAGGCTCACCATCGCTCCTGCCGCATCGCAGTAG

Structures

Toxin

• AlphaFold DB: A9BSX0

Antitoxin

• AlphaFold DB: A9BSW9