Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1100793..1102476 Replicon chromosome
Accession NZ_CP019171
Organism MAG: Delftia acidovorans isolate ANG1

Toxin (Protein)


Gene name doc Uniprot ID A9BQI6
Locus tag AO536_RS05080 Protein ID WP_012202882.1
Coordinates 1100793..1101647 (+) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID F6ALN8
Locus tag AO536_RS05085 Protein ID WP_012202883.1
Coordinates 1101670..1102476 (+) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AO536_RS05055 1096804..1097625 + 822 WP_012202877.1 2,5-didehydrogluconate reductase DkgB -
AO536_RS05060 1097782..1099461 + 1680 WP_012202878.1 long-chain-fatty-acid--CoA ligase -
AO536_RS05065 1099530..1099727 - 198 WP_192812337.1 hypothetical protein -
AO536_RS05070 1099745..1100062 + 318 WP_225971039.1 Lrp/AsnC family transcriptional regulator -
AO536_RS05075 1100248..1100778 + 531 WP_012202881.1 cupin domain-containing protein -
AO536_RS05080 1100793..1101647 + 855 WP_012202882.1 alpha/beta fold hydrolase Toxin
AO536_RS05085 1101670..1102476 + 807 WP_012202883.1 IclR family transcriptional regulator Antitoxin
AO536_RS05090 1102531..1103328 + 798 WP_043780656.1 aspartate dehydrogenase -
AO536_RS05095 1103440..1104195 + 756 WP_012202885.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
AO536_RS05100 1104444..1105607 + 1164 WP_221781674.1 IS481 family transposase -
AO536_RS05105 1105886..1106161 - 276 WP_012202887.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29659.91 Da        Isoelectric Point: 6.7493

>T71803 WP_012202882.1 NZ_CP019171:1100793-1101647 [Delftia acidovorans]
MTAQTLQRMEQRLQTQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALELAPRARVLAWDAPGYGR
STPLAPDAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T71803 NZ_CP019171:1100793-1101647 [Delftia acidovorans]
ATGACCGCGCAGACGCTGCAGCGCATGGAACAGCGCCTTCAGACGCAGTTCCCCGAACACCTCATCGCCCTGCCCGGTGG
CGCTCAGGCCGCCTGGCGCGAGGCCGGCGACACGGCCTCGGACTTTGCCGTGGTGATGCTGCACGGCATCAGCTCGGGCG
CCGCCTCCTGGCTGGACGTGGCCCTGGAGCTGGCGCCGCGCGCGCGTGTGCTGGCCTGGGACGCGCCCGGCTATGGCCGC
TCCACGCCGCTGGCACCCGACGCGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGCCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCCCTTCAGGAAAAAGGCATCGAAGGCCTGGCCGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCTGCCGGCTACGCCCAGGCCGTGGAGCTGC
TGTGCGGCAGCGACCTGGGGCAGGCGGCGGGGCAACTGGCCATGCCGGTCGAGGTCTGGGTGGGAGAGCACGACGTGGTC
ACGCCGCCCGCCGCCTGTGCGGCCTGGGCCGCAAGGCTGGGCGCCCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29330.45 Da        Isoelectric Point: 5.7085

>AT71803 WP_012202883.1 NZ_CP019171:1101670-1102476 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Download         Length: 807 bp

>AT71803 NZ_CP019171:1101670-1102476 [Delftia acidovorans]
ATGAGCGACACCTCCGAAACCCTCTCGAACGACAACGACCGCTACACCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCGCGTTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGAACATGGGGTATCTGCAACGCTCGGGCACCGAGTACCGGCTGGGCCTGTCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGGCGCTGTGCGAGCGCCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCCGTAGTCTACGTGGCGCGCATCGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGCCTGCCGGCCCATGCCACCGTGCTGGGCCGCGCCCTGCTGCAGGACATGGACGCA
GACCAGCTGCGCGAACTCTTCGGCGGCAGCGAGCTGCCGCAATTCTCGGAAAGCACCCCGCGCGACGTGCAGCAACTGCA
GCAGTTGCTGCTGCAGGACCGCGAGCGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATTGCCG
CACCCGTGCGCGATGCGCAGGGCCGCATCATCGCGGGCCTGGGCATGGCCGTGGCCTTTACCGAAATCGCACCCGGGCGC
ATGGCGCACTGGGTGGAACAGGTGCGCGAGGCCGCCGTCGAACTGACGGGCCACCTGCGCACCCAGCATCCTGGTTTTCT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9BQI6

Antitoxin

Source ID Structure
AlphaFold DB A0A031HDN8

References