Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3460942..3461584 Replicon chromosome
Accession NZ_CP019160
Organism Klebsiella pneumoniae strain GN-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BKY56_RS17395 Protein ID WP_075647414.1
Coordinates 3461411..3461584 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BKY56_RS17390 Protein ID WP_075647415.1
Coordinates 3460942..3461352 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKY56_RS17360 3456601..3457089 - 489 WP_048324916.1 DUF1441 family protein -
BKY56_RS17365 3457321..3457635 - 315 WP_077273936.1 hypothetical protein -
BKY56_RS17370 3457740..3458048 - 309 WP_075647417.1 hypothetical protein -
BKY56_RS17375 3459037..3459387 - 351 WP_016160650.1 hypothetical protein -
BKY56_RS17380 3459384..3459881 - 498 WP_075647416.1 lysozyme -
BKY56_RS17385 3459881..3460096 - 216 WP_017880269.1 class II holin family protein -
BKY56_RS17390 3460942..3461352 - 411 WP_075647415.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BKY56_RS17395 3461411..3461584 - 174 WP_075647414.1 type II toxin-antitoxin system HicA family toxin Toxin
BKY56_RS17400 3461850..3462713 + 864 WP_075647413.1 hypothetical protein -
BKY56_RS17405 3462976..3463392 + 417 WP_148666352.1 hypothetical protein -
BKY56_RS17410 3463408..3463773 - 366 WP_075647411.1 DUF1133 family protein -
BKY56_RS17415 3463792..3464772 - 981 WP_075647410.1 DUF968 domain-containing protein -
BKY56_RS17420 3464797..3465606 - 810 WP_075647409.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
BKY56_RS17425 3465603..3466517 - 915 WP_040188691.1 conserved phage C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rcsA 3430214..3520114 89900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(86-128)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6603.75 Da        Isoelectric Point: 11.3260

>T71790 WP_075647414.1 NZ_CP019160:c3461584-3461411 [Klebsiella pneumoniae]
VKQREFQRWLESQGVEITDGAKHLKLRLNGKRSVMPRHPGSEIVEQLRKAILKQLGL

Download         Length: 174 bp

>T71790 NZ_CP019160:c3461584-3461411 [Klebsiella pneumoniae]
GTGAAACAGCGCGAATTCCAGCGCTGGTTGGAATCTCAGGGGGTCGAAATCACTGACGGTGCAAAACATCTGAAGTTGAG
ACTGAACGGGAAGCGTAGCGTCATGCCTCGCCACCCGGGATCCGAGATTGTAGAACAGCTTCGTAAAGCTATTCTCAAAC
AACTAGGCCTGTAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15269.40 Da        Isoelectric Point: 4.4249

>AT71790 WP_075647415.1 NZ_CP019160:c3461352-3460942 [Klebsiella pneumoniae]
MRYPVNLSKAEEGGFFVEFPDIPEALTQGDTKEEALDNALDALVTAFEFYFEDGDRIPEPGVPTGDYVELPLSIEAKVLM
LNAFIESKLSQTELAAKMNVKKQEVTRLFDLKHSTKIDTIQKAVNSLGHRMELKYA

Download         Length: 411 bp

>AT71790 NZ_CP019160:c3461352-3460942 [Klebsiella pneumoniae]
ATGCGATATCCTGTAAACCTAAGTAAAGCTGAAGAAGGCGGATTCTTCGTAGAATTCCCGGATATACCTGAAGCTCTTAC
GCAGGGTGATACCAAAGAAGAAGCGCTTGATAACGCACTTGACGCTTTGGTAACGGCTTTCGAGTTTTACTTCGAAGATG
GAGATAGGATTCCGGAGCCTGGTGTACCGACAGGAGACTATGTAGAGTTACCGTTAAGTATTGAAGCTAAAGTATTAATG
TTAAATGCCTTTATTGAATCAAAATTGAGCCAAACTGAACTGGCTGCAAAAATGAATGTTAAAAAACAGGAAGTTACAAG
GTTGTTTGACCTTAAACATTCAACAAAAATTGATACAATTCAAAAGGCTGTCAACTCACTTGGACATAGAATGGAGTTAA
AGTATGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References