Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 518711..519227 Replicon chromosome
Accession NZ_CP019160
Organism Klebsiella pneumoniae strain GN-2

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag BKY56_RS02605 Protein ID WP_009309309.1
Coordinates 518943..519227 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BKY56_RS02600 Protein ID WP_002886901.1
Coordinates 518711..518953 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKY56_RS02585 514739..515479 + 741 WP_009486551.1 KDGP aldolase family protein -
BKY56_RS02590 515546..516700 + 1155 WP_020316350.1 lactonase family protein -
BKY56_RS02595 516723..518633 + 1911 WP_009486549.1 BglG family transcription antiterminator -
BKY56_RS02600 518711..518953 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BKY56_RS02605 518943..519227 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BKY56_RS02610 519231..519695 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BKY56_RS02615 520024..522162 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
BKY56_RS02620 522519..523262 - 744 WP_075647474.1 MurR/RpiR family transcriptional regulator -
BKY56_RS28645 523265..523438 - 174 WP_002886906.1 hypothetical protein -
BKY56_RS02625 523523..523831 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T71778 WP_009309309.1 NZ_CP019160:518943-519227 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T71778 NZ_CP019160:518943-519227 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT71778 WP_002886901.1 NZ_CP019160:518711-518953 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT71778 NZ_CP019160:518711-518953 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References