Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1863498..1864045 Replicon chromosome
Accession NZ_CP019121
Organism Vibrio vulnificus strain FORC_054

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag FORC54_RS09940 Protein ID WP_025548916.1
Coordinates 1863498..1863800 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag FORC54_RS09945 Protein ID WP_005448240.1
Coordinates 1863788..1864045 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC54_RS09875 1858667..1859197 - 531 WP_038940537.1 DUF2628 domain-containing protein -
FORC54_RS09880 1859208..1859348 - 141 WP_101958723.1 DUF3265 domain-containing protein -
FORC54_RS09890 1859679..1859840 - 162 WP_192811387.1 DUF3265 domain-containing protein -
FORC54_RS09895 1859803..1860246 - 444 WP_038940635.1 GNAT family N-acetyltransferase -
FORC54_RS09900 1860287..1860379 - 93 WP_199768196.1 DUF3265 domain-containing protein -
FORC54_RS09905 1860394..1861101 - 708 WP_101958708.1 hypothetical protein -
FORC54_RS09910 1861113..1861247 - 135 WP_101959132.1 DUF3265 domain-containing protein -
FORC54_RS09915 1861596..1861745 - 150 Protein_1835 DUF3265 domain-containing protein -
FORC54_RS09920 1861754..1862377 - 624 WP_101958724.1 hypothetical protein -
FORC54_RS09925 1862424..1862516 - 93 WP_199768199.1 DUF3265 domain-containing protein -
FORC54_RS09930 1862541..1863329 - 789 WP_101958726.1 BRO-like protein -
FORC54_RS09935 1863370..1863462 - 93 WP_101958727.1 DUF3265 domain-containing protein -
FORC54_RS09940 1863498..1863800 - 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC54_RS09945 1863788..1864045 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC54_RS09950 1864116..1864238 - 123 WP_080540727.1 DUF3265 domain-containing protein -
FORC54_RS09955 1864583..1864747 - 165 WP_101958728.1 DUF3265 domain-containing protein -
FORC54_RS09960 1865055..1865183 - 129 WP_080584345.1 DUF3265 domain-containing protein -
FORC54_RS24715 1865531..1865659 - 129 WP_086017805.1 DUF3265 domain-containing protein -
FORC54_RS09970 1866133..1866564 - 432 WP_101958627.1 hypothetical protein -
FORC54_RS09975 1866716..1867315 - 600 WP_039452830.1 hypothetical protein -
FORC54_RS09980 1867466..1867687 - 222 WP_005526706.1 VF530 family protein -
FORC54_RS09985 1867828..1867917 - 90 WP_072829120.1 DUF3265 domain-containing protein -
FORC54_RS09990 1868438..1868530 - 93 WP_199768200.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1477413..1923771 446358
- inside Integron - - 1680885..1885081 204196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T71774 WP_025548916.1 NZ_CP019121:c1863800-1863498 [Vibrio vulnificus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T71774 NZ_CP019121:c1863800-1863498 [Vibrio vulnificus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCTC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT71774 WP_005448240.1 NZ_CP019121:c1864045-1863788 [Vibrio vulnificus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT71774 NZ_CP019121:c1864045-1863788 [Vibrio vulnificus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGATAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References