Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1841556..1842115 Replicon chromosome
Accession NZ_CP019121
Organism Vibrio vulnificus strain FORC_054

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag FORC54_RS09665 Protein ID WP_005398411.1
Coordinates 1841837..1842115 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag FORC54_RS09660 Protein ID WP_005398409.1
Coordinates 1841556..1841840 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC54_RS09600 1836598..1836900 + 303 WP_101958703.1 hypothetical protein -
FORC54_RS09605 1837000..1837092 - 93 WP_006074995.1 DUF3265 domain-containing protein -
FORC54_RS09610 1837107..1837790 - 684 WP_101958705.1 hypothetical protein -
FORC54_RS09615 1838128..1839075 - 948 WP_101958593.1 IS30 family transposase -
FORC54_RS09630 1839663..1840040 - 378 Protein_1786 DUF2628 domain-containing protein -
FORC54_RS09635 1840068..1840160 - 93 WP_199768196.1 DUF3265 domain-containing protein -
FORC54_RS09640 1840175..1840882 - 708 WP_101958708.1 hypothetical protein -
FORC54_RS09645 1840894..1841040 - 147 WP_101958709.1 DUF3265 domain-containing protein -
FORC54_RS09655 1841363..1841479 - 117 WP_101958710.1 DUF3265 domain-containing protein -
FORC54_RS09660 1841556..1841840 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FORC54_RS09665 1841837..1842115 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FORC54_RS09675 1842264..1842551 - 288 WP_017049660.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC54_RS09680 1842548..1842829 - 282 WP_000086650.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC54_RS09685 1843027..1843536 - 510 WP_101958711.1 AAA family ATPase -
FORC54_RS09690 1843551..1843724 - 174 WP_101958712.1 DUF3265 domain-containing protein -
FORC54_RS09695 1843678..1844007 - 330 WP_101958713.1 DUF2314 domain-containing protein -
FORC54_RS09700 1844033..1844149 - 117 WP_101959126.1 DUF3265 domain-containing protein -
FORC54_RS09705 1844146..1844982 - 837 WP_101958714.1 hypothetical protein -
FORC54_RS09710 1844994..1845131 - 138 WP_101958715.1 DUF3265 domain-containing protein -
FORC54_RS09715 1845497..1845607 - 111 WP_095490667.1 DUF3265 domain-containing protein -
FORC54_RS09720 1845950..1846078 - 129 WP_101959127.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1477413..1923771 446358
- flank IS/Tn - - 1838128..1839075 947
- inside Integron - - 1680885..1885081 204196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T71772 WP_005398411.1 NZ_CP019121:1841837-1842115 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T71772 NZ_CP019121:1841837-1842115 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT71772 WP_005398409.1 NZ_CP019121:1841556-1841840 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT71772 NZ_CP019121:1841556-1841840 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGTAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References