Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1804945..1805510 Replicon chromosome
Accession NZ_CP019121
Organism Vibrio vulnificus strain FORC_054

Toxin (Protein)


Gene name relE Uniprot ID A0A0F2IXR1
Locus tag FORC54_RS09265 Protein ID WP_017049660.1
Coordinates 1804945..1805232 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W9USL4
Locus tag FORC54_RS09270 Protein ID WP_000086650.1
Coordinates 1805229..1805510 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC54_RS09210 1800238..1800330 - 93 WP_199768194.1 DUF3265 domain-containing protein -
FORC54_RS09215 1800320..1801165 - 846 WP_101958675.1 hypothetical protein -
FORC54_RS09220 1801184..1801306 - 123 WP_101959114.1 DUF3265 domain-containing protein -
FORC54_RS09225 1801648..1801776 - 129 WP_101959113.1 DUF3265 domain-containing protein -
FORC54_RS09230 1802247..1802627 - 381 WP_101958676.1 hypothetical protein -
FORC54_RS09235 1802707..1803444 - 738 WP_158636616.1 hypothetical protein -
FORC54_RS09240 1803472..1803582 - 111 Protein_1717 DUF3265 domain-containing protein -
FORC54_RS09245 1803579..1803833 - 255 WP_101958678.1 hypothetical protein -
FORC54_RS09250 1803848..1803988 - 141 WP_101958679.1 DUF3265 domain-containing protein -
FORC54_RS09255 1804333..1804461 - 129 WP_101959116.1 DUF3265 domain-containing protein -
FORC54_RS09265 1804945..1805232 - 288 WP_017049660.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC54_RS09270 1805229..1805510 - 282 WP_000086650.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC54_RS09275 1805601..1805690 - 90 WP_101959117.1 DUF3265 domain-containing protein -
FORC54_RS09280 1805708..1806175 - 468 WP_101958680.1 hypothetical protein -
FORC54_RS09285 1806203..1806295 - 93 WP_072599414.1 DUF3265 domain-containing protein -
FORC54_RS09290 1806320..1806835 - 516 WP_101958681.1 GNAT family N-acetyltransferase -
FORC54_RS09295 1807235..1807429 - 195 WP_101958682.1 DUF3265 domain-containing protein -
FORC54_RS24820 1808172..1808243 - 72 WP_165386926.1 hypothetical protein -
FORC54_RS09300 1808291..1808788 - 498 WP_038964980.1 DUF2867 domain-containing protein -
FORC54_RS09305 1808935..1809738 - 804 WP_101958683.1 hypothetical protein -
FORC54_RS09310 1809892..1810509 - 618 WP_101958684.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1477413..1923771 446358
- inside Integron - - 1680885..1885081 204196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.71 Da        Isoelectric Point: 5.6023

>T71771 WP_017049660.1 NZ_CP019121:c1805232-1804945 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T71771 NZ_CP019121:c1805232-1804945 [Vibrio vulnificus]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCTTCAGC
TGCAGAAAAGTGGGTGAATGATGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGCCATTACCGCATTATTTATAGTTTGGGCCTCGAAATACGAGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10347.90 Da        Isoelectric Point: 5.1548

>AT71771 WP_000086650.1 NZ_CP019121:c1805510-1805229 [Vibrio vulnificus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT71771 NZ_CP019121:c1805510-1805229 [Vibrio vulnificus]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAATATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTGTCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2IXR1

Antitoxin

Source ID Structure
AlphaFold DB W9USL4

References