Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1750134..1750650 Replicon chromosome
Accession NZ_CP019121
Organism Vibrio vulnificus strain FORC_054

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag FORC54_RS08645 Protein ID WP_005464459.1
Coordinates 1750134..1750403 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U2ZH00
Locus tag FORC54_RS08650 Protein ID WP_005526636.1
Coordinates 1750396..1750650 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC54_RS24810 1745316..1745393 - 78 WP_130355399.1 hypothetical protein -
FORC54_RS08580 1745455..1745676 - 222 WP_005526706.1 VF530 family protein -
FORC54_RS08590 1746246..1746419 - 174 WP_101958625.1 DUF3265 domain-containing protein -
FORC54_RS08600 1746768..1746896 - 129 WP_017428800.1 DUF3265 domain-containing protein -
FORC54_RS08605 1747565..1748029 + 465 WP_055065351.1 hypothetical protein -
FORC54_RS08610 1748113..1748322 - 210 WP_101958626.1 hypothetical protein -
FORC54_RS08615 1748348..1748470 - 123 WP_101959101.1 DUF3265 domain-containing protein -
FORC54_RS08620 1748805..1748948 - 144 Protein_1619 DUF3265 domain-containing protein -
FORC54_RS08625 1748990..1749235 + 246 WP_017420672.1 type II toxin-antitoxin system CcdA family antitoxin -
FORC54_RS08630 1749235..1749552 + 318 WP_061900738.1 CcdB family protein -
FORC54_RS08635 1749560..1749670 - 111 WP_072599421.1 DUF3265 domain-containing protein -
FORC54_RS08645 1750134..1750403 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
FORC54_RS08650 1750396..1750650 - 255 WP_005526636.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FORC54_RS08655 1750742..1750864 - 123 WP_180981939.1 DUF3265 domain-containing protein -
FORC54_RS08660 1751214..1751342 - 129 WP_086017805.1 DUF3265 domain-containing protein -
FORC54_RS08665 1751816..1752247 - 432 WP_101958627.1 hypothetical protein -
FORC54_RS08670 1752257..1752388 - 132 WP_101958628.1 DUF3265 domain-containing protein -
FORC54_RS08675 1752736..1752864 - 129 WP_101959103.1 DUF3265 domain-containing protein -
FORC54_RS08685 1753046..1753309 + 264 Protein_1630 transposase -
FORC54_RS08690 1753556..1754599 - 1044 WP_101958368.1 IS110 family transposase -
FORC54_RS08695 1754673..1755584 + 912 Protein_1632 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1477413..1923771 446358
- inside Integron - - 1680885..1885081 204196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T71770 WP_005464459.1 NZ_CP019121:c1750403-1750134 [Vibrio vulnificus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T71770 NZ_CP019121:c1750403-1750134 [Vibrio vulnificus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGTTCTCCATTTGAGGGTATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAGGCCATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 5.0623

>AT71770 WP_005526636.1 NZ_CP019121:c1750650-1750396 [Vibrio vulnificus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT71770 NZ_CP019121:c1750650-1750396 [Vibrio vulnificus]
ATGAGAATCGTATCTTTTACTGAAGCAAGAAATGGTCTTAAAGCTGTTTTGGATGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAAGATGCTGTGGTTATGTCCTTAGATTACTACAATAGCCTTATGGAGACAGTGCACT
TACTACGCTCTCCTCAAAACGCTGAACACTTAAACCGTTCTATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A244CM06

References