Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1743114..1743652 | Replicon | chromosome |
| Accession | NZ_CP019121 | ||
| Organism | Vibrio vulnificus strain FORC_054 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | FORC54_RS08555 | Protein ID | WP_017420621.1 |
| Coordinates | 1743353..1743652 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0F2HR74 |
| Locus tag | FORC54_RS08550 | Protein ID | WP_011080384.1 |
| Coordinates | 1743114..1743356 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC54_RS08485 | 1738837..1739289 | - | 453 | WP_101958617.1 | GNAT family N-acetyltransferase | - |
| FORC54_RS08490 | 1739443..1739685 | - | 243 | WP_101958618.1 | hypothetical protein | - |
| FORC54_RS08495 | 1739663..1739824 | - | 162 | WP_101958619.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08500 | 1739857..1740207 | - | 351 | WP_038940876.1 | hypothetical protein | - |
| FORC54_RS08515 | 1740887..1741318 | - | 432 | WP_000074956.1 | hypothetical protein | - |
| FORC54_RS08520 | 1741336..1741488 | - | 153 | WP_101958621.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08525 | 1741454..1741975 | - | 522 | WP_017420670.1 | GrpB family protein | - |
| FORC54_RS08530 | 1741992..1742093 | - | 102 | WP_101959098.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08535 | 1742111..1742419 | - | 309 | WP_017428770.1 | hypothetical protein | - |
| FORC54_RS08540 | 1742457..1742579 | - | 123 | WP_080480934.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08550 | 1743114..1743356 | + | 243 | WP_011080384.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FORC54_RS08555 | 1743353..1743652 | + | 300 | WP_017420621.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC54_RS08560 | 1743777..1744352 | - | 576 | WP_101958622.1 | hypothetical protein | - |
| FORC54_RS08565 | 1744380..1744514 | - | 135 | WP_101958623.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08575 | 1744849..1744976 | - | 128 | Protein_1611 | DUF3265 domain-containing protein | - |
| FORC54_RS24810 | 1745316..1745393 | - | 78 | WP_130355399.1 | hypothetical protein | - |
| FORC54_RS08580 | 1745455..1745676 | - | 222 | WP_005526706.1 | VF530 family protein | - |
| FORC54_RS08590 | 1746246..1746419 | - | 174 | WP_101958625.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08600 | 1746768..1746896 | - | 129 | WP_017428800.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08605 | 1747565..1748029 | + | 465 | WP_055065351.1 | hypothetical protein | - |
| FORC54_RS08610 | 1748113..1748322 | - | 210 | WP_101958626.1 | hypothetical protein | - |
| FORC54_RS08615 | 1748348..1748470 | - | 123 | WP_101959101.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 | 1477413..1923771 | 446358 | |
| - | inside | Integron | - | - | 1680885..1885081 | 204196 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11669.37 Da Isoelectric Point: 9.9572
>T71769 WP_017420621.1 NZ_CP019121:1743353-1743652 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA
Download Length: 300 bp
>T71769 NZ_CP019121:1743353-1743652 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATCCTTCACAAAAGCATGGATGTGAATCCAATTTTGGGCGCATAA
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATCCTTCACAAAAGCATGGATGTGAATCCAATTTTGGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8953.88 Da Isoelectric Point: 4.2213
>AT71769 WP_011080384.1 NZ_CP019121:1743114-1743356 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK
Download Length: 243 bp
>AT71769 NZ_CP019121:1743114-1743356 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGATGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAATACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGATGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAATACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|