Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1712599..1713127 | Replicon | chromosome |
| Accession | NZ_CP019121 | ||
| Organism | Vibrio vulnificus strain FORC_054 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | FORC54_RS08190 | Protein ID | WP_038970001.1 |
| Coordinates | 1712599..1712886 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | W9V7T8 |
| Locus tag | FORC54_RS08195 | Protein ID | WP_001250181.1 |
| Coordinates | 1712876..1713127 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC54_RS08115 | 1707780..1707890 | - | 111 | Protein_1537 | DUF3265 domain-containing protein | - |
| FORC54_RS08120 | 1707887..1708306 | - | 420 | WP_058666901.1 | hypothetical protein | - |
| FORC54_RS24640 | 1708296..1708427 | - | 132 | WP_199768206.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08135 | 1708905..1709471 | - | 567 | WP_146030953.1 | hypothetical protein | - |
| FORC54_RS08140 | 1709476..1709613 | - | 138 | WP_101959087.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08145 | 1709957..1710100 | - | 144 | WP_101959088.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08150 | 1710082..1710513 | - | 432 | WP_000074956.1 | hypothetical protein | - |
| FORC54_RS08155 | 1710531..1710652 | - | 122 | Protein_1544 | DUF3265 domain-containing protein | - |
| FORC54_RS08160 | 1710649..1711092 | - | 444 | WP_101958600.1 | GNAT family N-acetyltransferase | - |
| FORC54_RS08165 | 1711095..1711244 | - | 150 | WP_101959089.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08170 | 1711266..1711484 | - | 219 | WP_005527676.1 | hypothetical protein | - |
| FORC54_RS08180 | 1711716..1712432 | - | 717 | WP_101958601.1 | hypothetical protein | - |
| FORC54_RS08190 | 1712599..1712886 | - | 288 | WP_038970001.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC54_RS08195 | 1712876..1713127 | - | 252 | WP_001250181.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC54_RS08200 | 1713187..1713330 | - | 144 | WP_101958602.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08205 | 1713679..1713834 | - | 156 | WP_101958603.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08210 | 1713812..1714327 | - | 516 | WP_101958604.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08220 | 1714676..1715623 | + | 948 | WP_101958593.1 | IS30 family transposase | - |
| FORC54_RS08225 | 1715660..1715920 | - | 261 | Protein_1555 | metal ABC transporter ATPase | - |
| FORC54_RS08230 | 1715945..1716076 | - | 132 | Protein_1556 | DUF3265 domain-containing protein | - |
| FORC54_RS08235 | 1716406..1716534 | - | 129 | WP_101959090.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08240 | 1716885..1717025 | - | 141 | WP_101959091.1 | DUF3265 domain-containing protein | - |
| FORC54_RS08245 | 1717021..1717452 | - | 432 | WP_072609930.1 | hypothetical protein | - |
| FORC54_RS08250 | 1717612..1717959 | - | 348 | WP_101958605.1 | hypothetical protein | - |
| FORC54_RS08255 | 1717975..1718109 | - | 135 | WP_101958606.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 | 1477413..1923771 | 446358 | |
| - | inside | Integron | - | - | 1680885..1885081 | 204196 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11097.01 Da Isoelectric Point: 10.6166
>T71768 WP_038970001.1 NZ_CP019121:c1712886-1712599 [Vibrio vulnificus]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSSKLRGYESVYKIKLRTSGYRLAYEVIDNEVVVYVLAVGR
RDKDAVYKKLASRFS
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSSKLRGYESVYKIKLRTSGYRLAYEVIDNEVVVYVLAVGR
RDKDAVYKKLASRFS
Download Length: 288 bp
>T71768 NZ_CP019121:c1712886-1712599 [Vibrio vulnificus]
ATGACTTATAAGTTAAAGTTTTTGCCAGCAGCCCAAAAGGAGTGGAGTAAGCTAGCGCCAACGATTCAGAGTCAATTTAA
AAAGAAACTCAAAGAAAGGCTAGAAAACCCCCACGTCCCATCATCAAAATTACGAGGTTATGAATCTGTTTACAAAATCA
AACTTCGTACATCTGGTTATCGTTTGGCTTATGAAGTCATCGATAATGAAGTTGTCGTTTATGTACTCGCTGTTGGTAGA
CGAGATAAAGACGCTGTTTATAAGAAGCTGGCTTCACGCTTCAGCTAG
ATGACTTATAAGTTAAAGTTTTTGCCAGCAGCCCAAAAGGAGTGGAGTAAGCTAGCGCCAACGATTCAGAGTCAATTTAA
AAAGAAACTCAAAGAAAGGCTAGAAAACCCCCACGTCCCATCATCAAAATTACGAGGTTATGAATCTGTTTACAAAATCA
AACTTCGTACATCTGGTTATCGTTTGGCTTATGAAGTCATCGATAATGAAGTTGTCGTTTATGTACTCGCTGTTGGTAGA
CGAGATAAAGACGCTGTTTATAAGAAGCTGGCTTCACGCTTCAGCTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9170.32 Da Isoelectric Point: 4.0197
>AT71768 WP_001250181.1 NZ_CP019121:c1713127-1712876 [Vibrio vulnificus]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLMDMLDDYELSQIVDSRRGDLSQAVEINI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLMDMLDDYELSQIVDSRRGDLSQAVEINI
DDL
Download Length: 252 bp
>AT71768 NZ_CP019121:c1713127-1712876 [Vibrio vulnificus]
ATGAGACAGGTACTAGCGAATTGCTCTGCCAGTATTTCAGAGTTAAAGAAAAATCCAACTGCTCTTTTGAACGAGGCTGA
TGGTTCAGCTATTGCGATCCTTAACCACAACAAACCCGCAGCTTACCTTGTACCGGCTGAAACTTACGAGTATCTGATGG
ATATGCTTGATGATTATGAGCTTTCCCAAATAGTAGATAGTCGTCGTGGTGATTTGTCGCAAGCTGTGGAAATCAATATT
GATGACTTATAA
ATGAGACAGGTACTAGCGAATTGCTCTGCCAGTATTTCAGAGTTAAAGAAAAATCCAACTGCTCTTTTGAACGAGGCTGA
TGGTTCAGCTATTGCGATCCTTAACCACAACAAACCCGCAGCTTACCTTGTACCGGCTGAAACTTACGAGTATCTGATGG
ATATGCTTGATGATTATGAGCTTTCCCAAATAGTAGATAGTCGTCGTGGTGATTTGTCGCAAGCTGTGGAAATCAATATT
GATGACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|