Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1703247..1704013 Replicon chromosome
Accession NZ_CP019121
Organism Vibrio vulnificus strain FORC_054

Toxin (Protein)


Gene name - Uniprot ID A0A2K7SQA7
Locus tag FORC54_RS08075 Protein ID WP_017420533.1
Coordinates 1703516..1704013 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag FORC54_RS08070 Protein ID WP_017420534.1
Coordinates 1703247..1703519 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC54_RS08015 1698460..1698582 - 123 WP_101959084.1 DUF3265 domain-containing protein -
FORC54_RS08020 1698937..1699044 - 108 WP_101959083.1 DUF3265 domain-containing protein -
FORC54_RS08025 1699245..1700192 - 948 WP_101958593.1 IS30 family transposase -
FORC54_RS08030 1700355..1700477 - 123 WP_080729780.1 DUF3265 domain-containing protein -
FORC54_RS08035 1700822..1700950 - 129 WP_101959085.1 DUF3265 domain-containing protein -
FORC54_RS08040 1700971..1701441 - 471 WP_103155416.1 metal ABC transporter ATPase -
FORC54_RS24795 1701445..1701563 - 119 Protein_1521 DUF3265 domain-containing protein -
FORC54_RS08045 1701907..1702035 - 129 Protein_1522 DUF3265 domain-containing protein -
FORC54_RS08050 1702032..1702529 - 498 WP_101958594.1 DUF2867 domain-containing protein -
FORC54_RS08055 1702539..1702709 - 171 WP_101958595.1 DUF3265 domain-containing protein -
FORC54_RS08060 1702682..1703011 - 330 WP_072609950.1 hypothetical protein -
FORC54_RS24800 1703045..1703137 - 93 WP_079741491.1 DUF3265 domain-containing protein -
FORC54_RS08070 1703247..1703519 + 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
FORC54_RS08075 1703516..1704013 + 498 WP_017420533.1 GNAT family N-acetyltransferase Toxin
FORC54_RS08080 1704036..1704167 - 132 WP_101958596.1 DUF3265 domain-containing protein -
FORC54_RS08085 1704154..1704408 - 255 WP_052132573.1 hypothetical protein -
FORC54_RS08090 1704560..1705048 - 489 WP_101958597.1 hypothetical protein -
FORC54_RS08095 1705455..1706099 - 645 WP_101958598.1 pentapeptide repeat-containing protein -
FORC54_RS08100 1706124..1706246 - 123 Protein_1533 DUF3265 domain-containing protein -
FORC54_RS24635 1706592..1706669 - 78 WP_130253552.1 hypothetical protein -
FORC54_RS08105 1706771..1707190 + 420 WP_017420365.1 BLUF domain-containing protein -
FORC54_RS08110 1707315..1707761 - 447 WP_017420626.1 GNAT family N-acetyltransferase -
FORC54_RS08115 1707780..1707890 - 111 Protein_1537 DUF3265 domain-containing protein -
FORC54_RS08120 1707887..1708306 - 420 WP_058666901.1 hypothetical protein -
FORC54_RS24640 1708296..1708427 - 132 WP_199768206.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1477413..1923771 446358
- inside Integron - - 1680885..1885081 204196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-151)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18467.13 Da        Isoelectric Point: 8.8117

>T71767 WP_017420533.1 NZ_CP019121:1703516-1704013 [Vibrio vulnificus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFHDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T71767 NZ_CP019121:1703516-1704013 [Vibrio vulnificus]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTACCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGATTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAACTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTCATGATGCCGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT71767 WP_017420534.1 NZ_CP019121:1703247-1703519 [Vibrio vulnificus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT71767 NZ_CP019121:1703247-1703519 [Vibrio vulnificus]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGATCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SQA7

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References