Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 662261..664089 Replicon chromosome
Accession NZ_CP019121
Organism Vibrio vulnificus strain FORC_054

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FORC54_RS03120 Protein ID WP_180981922.1
Coordinates 662728..664089 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FORC54_RS03115 Protein ID WP_017420006.1
Coordinates 662261..662743 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC54_RS03095 658273..658827 + 555 WP_011078504.1 hypothetical protein -
FORC54_RS03100 658829..659584 + 756 WP_101958361.1 NRDE family protein -
FORC54_RS03105 659599..660036 + 438 WP_101958362.1 YHS domain-containing protein -
FORC54_RS03110 660079..661821 + 1743 WP_038963538.1 lysophospholipid acyltransferase family protein -
FORC54_RS03115 662261..662743 - 483 WP_017420006.1 helix-turn-helix domain-containing protein Antitoxin
FORC54_RS03120 662728..664089 - 1362 WP_180981922.1 type II toxin-antitoxin system HipA family toxin Toxin
FORC54_RS03125 664742..665581 - 840 WP_101958364.1 hypothetical protein -
FORC54_RS03130 665742..666077 + 336 WP_101958365.1 hypothetical protein -
FORC54_RS03135 666130..666468 - 339 WP_101958366.1 hypothetical protein -
FORC54_RS03140 666531..667478 - 948 WP_011988311.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 662261..677053 14792
- flank IS/Tn - - 666531..667478 947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-140)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51382.17 Da        Isoelectric Point: 4.8210

>T71765 WP_180981922.1 NZ_CP019121:c664089-662728 [Vibrio vulnificus]
MEELTVQAFIRGEWIDIGIISFPKSSQHSFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYILLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIA
TEGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T71765 NZ_CP019121:c664089-662728 [Vibrio vulnificus]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAGTTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCGAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGACCTGAGTTCTGATGAACAAGACTATATTTT
GCTCAAGTTTGGCACAATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGACCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACCGAAATGGGAGTCGAAACGATCGCC
ACCGAAGGCATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGATGTTCAAATTATTGAACA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTCGTCGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAAGTGTTATTACAAGAACTAGAGGTTACTGCAAGTAAATGCATTGATTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17505.02 Da        Isoelectric Point: 10.8446

>AT71765 WP_017420006.1 NZ_CP019121:c662743-662261 [Vibrio vulnificus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKAGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT71765 NZ_CP019121:c662743-662261 [Vibrio vulnificus]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGGCTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
CGATGTCTCAAGAAAAACACTGTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References