Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2150715..2151229 Replicon chromosome
Accession NZ_CP019117
Organism Staphylococcus aureus strain SJTUF_J27

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag BRL61_RS11105 Protein ID WP_000581791.1
Coordinates 2150715..2150924 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag BRL61_RS11110 Protein ID WP_000138934.1
Coordinates 2150936..2151229 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRL61_RS11085 2146604..2147674 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
BRL61_RS11090 2147992..2149194 + 1203 WP_001109939.1 rod shape-determining protein RodA -
BRL61_RS14820 2149355..2150038 - 684 Protein_2043 transposase -
BRL61_RS11100 2150450..2150587 - 138 WP_000828354.1 hypothetical protein -
BRL61_RS11105 2150715..2150924 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
BRL61_RS11110 2150936..2151229 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
BRL61_RS11115 2151395..2152879 + 1485 WP_000571560.1 cardiolipin synthase -
BRL61_RS11120 2152907..2153554 + 648 WP_001187612.1 HD domain-containing protein -
BRL61_RS11135 2154167..2155039 - 873 WP_000725802.1 membrane protein insertase YidC -
BRL61_RS11140 2155125..2155766 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2149355..2149531 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T71758 WP_000581791.1 NZ_CP019117:c2150924-2150715 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T71758 NZ_CP019117:c2150924-2150715 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT71758 WP_000138934.1 NZ_CP019117:c2151229-2150936 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT71758 NZ_CP019117:c2151229-2150936 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References