71753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 869260..869737 Replicon chromosome
Accession NZ_CP019117
Organism Staphylococcus aureus strain SJTUF_J27

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BRL61_RS04380 Protein ID WP_000052076.1
Coordinates 869260..869448 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BRL61_RS04385 Protein ID WP_001059690.1
Coordinates 869477..869737 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRL61_RS04350 865213..865770 + 558 WP_000824491.1 hypothetical protein -
BRL61_RS04355 866111..866797 + 687 WP_001574556.1 thermonuclease family protein -
BRL61_RS04360 867154..867354 + 201 WP_001059082.1 cold-shock protein -
BRL61_RS04365 867851..868069 - 219 WP_000005879.1 hypothetical protein -
BRL61_RS04370 868131..868415 - 285 WP_001004401.1 hypothetical protein -
BRL61_RS04375 868503..869072 - 570 WP_001106663.1 hypothetical protein -
BRL61_RS04380 869260..869448 - 189 WP_000052076.1 hypothetical protein Toxin
BRL61_RS04385 869477..869737 - 261 WP_001059690.1 hypothetical protein Antitoxin
BRL61_RS04390 870078..870281 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BRL61_RS04395 870278..870514 - 237 WP_000368687.1 hypothetical protein -
BRL61_RS04400 870739..871320 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
BRL61_RS04405 871393..872010 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
BRL61_RS04410 872166..872660 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
BRL61_RS04415 873059..873481 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
BRL61_RS04420 873629..874345 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T71753 WP_000052076.1 NZ_CP019117:c869448-869260 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T71753 NZ_CP019117:c869448-869260 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT71753 WP_001059690.1 NZ_CP019117:c869737-869477 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT71753 NZ_CP019117:c869737-869477 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References