Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3239720..3241343 Replicon chromosome
Accession NZ_CP019113
Organism Enterobacter sp. SA187

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BMF08_RS15570 Protein ID WP_072568453.1
Coordinates 3240018..3241343 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BMF08_RS15565 Protein ID WP_072568452.1
Coordinates 3239720..3240013 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF08_RS15540 3235521..3235787 + 267 WP_072568447.1 VF530 family protein -
BMF08_RS15545 3236099..3236311 + 213 WP_072568448.1 RNA chaperone/antiterminator CspA -
BMF08_RS15550 3236438..3238534 - 2097 WP_072568449.1 pyrroloquinoline quinone-dependent dehydrogenase -
BMF08_RS15555 3238545..3238910 - 366 WP_072568450.1 hypothetical protein -
BMF08_RS15560 3239158..3239481 + 324 WP_072568451.1 hypothetical protein -
BMF08_RS15565 3239720..3240013 + 294 WP_072568452.1 helix-turn-helix domain-containing protein Antitoxin
BMF08_RS15570 3240018..3241343 + 1326 WP_072568453.1 type II toxin-antitoxin system HipA family toxin Toxin
BMF08_RS15575 3241578..3242192 - 615 WP_072568454.1 TetR/AcrR family transcriptional regulator -
BMF08_RS15580 3242266..3242979 + 714 WP_072568455.1 SDR family oxidoreductase -
BMF08_RS15585 3243034..3244029 - 996 WP_072568456.1 DUF2891 domain-containing protein -
BMF08_RS15590 3244056..3245042 - 987 WP_072568457.1 DUF979 domain-containing protein -
BMF08_RS15595 3245039..3245761 - 723 WP_072568458.1 DUF969 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50088.24 Da        Isoelectric Point: 6.1905

>T71740 WP_072568453.1 NZ_CP019113:3240018-3241343 [Enterobacter sp. SA187]
MSRIKPRLAIWMNGIHVGFWEKSRGEDLLRYLPEWIADGQGRPLSLSLPFTPGNQAWRGNIVRDYFDNLLPDSEGIRRRL
AMRYQAESLEPFDLLTELGKDCVGAIQLLHEDEEPTDLYSVKYRPLSASEIATALRNTTQVLLPGRQDDANDLCLSIAGA
QEKTALLWHEGQWCMPEGNTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLLLEHYGIPVARTEIAQFEDQKALVVARF
DRKWSADRQWIIRLPQEDMCQALGVSPLRKYQADGGPGISDIMEILSHSDLAEHDRAQFFRAQIIFWLMAATDGHAKNFS
IAIAPQGRYHLTPLYDVLSAWSVIGHGNNQIAWQKCKLAMAVRGSSNYYQIYRIQKRHWINHGKLAGLGEQQIETMLDEI
ISVTPGVIDRVMALLPQTYPQELADSIFNGIRQQCRHLEEK

Download         Length: 1326 bp

>T71740 NZ_CP019113:3240018-3241343 [Enterobacter sp. SA187]
ATGAGCAGGATAAAGCCGCGTTTAGCAATATGGATGAATGGCATCCACGTCGGATTCTGGGAGAAAAGCAGAGGGGAAGA
TTTATTGCGCTATCTGCCGGAATGGATTGCTGACGGGCAGGGCAGGCCTTTATCACTGTCCCTTCCTTTTACACCCGGTA
ATCAAGCCTGGCGCGGGAATATTGTCCGCGACTATTTTGATAATTTATTACCCGACAGTGAAGGGATACGCCGACGCCTG
GCGATGCGCTATCAGGCAGAAAGTCTTGAACCTTTTGACCTGCTGACAGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
ACTTTTGCATGAAGACGAGGAGCCCACGGATTTATATTCCGTAAAATATCGTCCGCTTTCTGCATCAGAAATCGCGACAG
CCTTGCGAAATACTACCCAGGTATTGCTGCCCGGCAGGCAGGATGATGCTAACGATCTGTGTTTATCGATTGCCGGCGCG
CAGGAAAAAACAGCCTTACTGTGGCATGAAGGCCAGTGGTGCATGCCCGAAGGTAATACGCCGACGACCCATATTTTCAA
GTTACCGCTCGGGCTGGTCGGCAATATGAAAGCTGATATGAGTACGTCAGTAGAAAATGAATGGCTGTGTTCGTTGCTTC
TTGAACACTACGGCATCCCCGTGGCACGAACGGAGATCGCGCAGTTTGAAGATCAGAAGGCCCTGGTGGTAGCGCGTTTT
GACCGGAAATGGTCCGCCGATCGGCAGTGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCTCTGGGCGTTTCTCC
TTTACGAAAATACCAGGCGGACGGTGGGCCGGGTATTTCGGACATTATGGAAATACTGAGTCATTCTGACCTGGCTGAAC
ATGACAGAGCGCAGTTCTTCAGAGCGCAGATTATTTTCTGGCTGATGGCTGCAACGGACGGCCACGCCAAAAATTTCAGT
ATCGCGATCGCGCCGCAGGGCCGTTATCATCTGACGCCGCTGTATGACGTTTTGTCGGCATGGTCGGTGATCGGTCACGG
GAATAATCAGATCGCCTGGCAGAAATGCAAGCTGGCGATGGCCGTCCGGGGCAGCAGCAATTATTACCAGATTTACCGCA
TACAAAAACGGCACTGGATCAACCATGGCAAGCTGGCTGGCCTGGGTGAGCAGCAGATAGAAACCATGCTGGATGAAATT
ATTTCCGTGACGCCGGGCGTCATTGACCGTGTTATGGCGTTACTTCCGCAGACGTATCCGCAGGAACTTGCTGACAGTAT
TTTTAATGGCATCAGGCAGCAATGCAGGCATCTGGAAGAAAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10807.38 Da        Isoelectric Point: 10.3760

>AT71740 WP_072568452.1 NZ_CP019113:3239720-3240013 [Enterobacter sp. SA187]
MKNVYPLKTLNQLRPLLLGFRKAHGLTQKEVSERLGVTQQTYARLEANPASASIERLFKVFSVLGVEISLSSATLASENR
QAEGNSDLHSPARLEKW

Download         Length: 294 bp

>AT71740 NZ_CP019113:3239720-3240013 [Enterobacter sp. SA187]
ATGAAAAATGTTTACCCGTTAAAAACGCTTAACCAGCTGCGTCCATTACTCCTTGGTTTTCGCAAAGCGCATGGCCTGAC
GCAAAAAGAGGTGTCCGAAAGGTTAGGCGTAACGCAGCAGACTTACGCCCGTCTGGAGGCCAATCCTGCCAGTGCCAGCA
TTGAGCGCCTGTTTAAGGTGTTTTCCGTCCTGGGTGTCGAAATCAGCCTTTCCTCAGCGACCCTTGCCTCAGAGAACAGG
CAGGCGGAGGGAAATTCAGATTTACATTCACCTGCACGGCTGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References