Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2256910..2257524 Replicon chromosome
Accession NZ_CP019113
Organism Enterobacter sp. SA187

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag BMF08_RS10705 Protein ID WP_072567578.1
Coordinates 2256910..2257128 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag BMF08_RS10710 Protein ID WP_072567579.1
Coordinates 2257150..2257524 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF08_RS10675 2252147..2253346 - 1200 WP_072567572.1 starvation-sensing protein RspA -
BMF08_RS10680 2253624..2255000 + 1377 WP_072567573.1 PTS transporter subunit EIIC -
BMF08_RS10685 2255156..2255416 + 261 WP_072567574.1 type B 50S ribosomal protein L31 -
BMF08_RS10690 2255420..2255560 + 141 WP_072567575.1 type B 50S ribosomal protein L36 -
BMF08_RS10695 2255586..2256056 - 471 WP_072567576.1 YlaC family protein -
BMF08_RS10700 2256161..2256727 - 567 WP_072567577.1 maltose O-acetyltransferase -
BMF08_RS10705 2256910..2257128 - 219 WP_072567578.1 hemolysin expression modulator Hha Toxin
BMF08_RS10710 2257150..2257524 - 375 WP_072567579.1 Hha toxicity modulator TomB Antitoxin
BMF08_RS10715 2258043..2261192 - 3150 WP_072567580.1 multidrug efflux RND transporter permease subunit AcrB -
BMF08_RS10720 2261215..2262411 - 1197 WP_072567581.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.99 Da        Isoelectric Point: 8.9008

>T71738 WP_072567578.1 NZ_CP019113:c2257128-2256910 [Enterobacter sp. SA187]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDPELTVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T71738 NZ_CP019113:c2257128-2256910 [Enterobacter sp. SA187]
ATGTCTGATAAACCATTAACCAAGACTGATTATTTGATGCGCCTGAGGCGCTGTCAGACTATTGATACGCTGGAACGCGT
CATTGAAAAGAATAAATATGAGCTGTCGGATCCGGAACTGACCGTATTTTATTCAGCGGCGGATCACCGTCTGGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATTCCGTCGTCGGTTTGGAAATTCGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14505.34 Da        Isoelectric Point: 5.1573

>AT71738 WP_072567579.1 NZ_CP019113:c2257524-2257150 [Enterobacter sp. SA187]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESHHGWVNDPTSAINLQLNELVEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTEDLQKWRKSGNRLFRCFLNVSRANPVSLSC

Download         Length: 375 bp

>AT71738 NZ_CP019113:c2257524-2257150 [Enterobacter sp. SA187]
ATGGACGAATACTCGCCAAAAAGGCATGATATTGCGCAGCTGAAATTTCTTTGTGAAACCCTGTACCATGATTGCCTCGC
CAATCTGGAAGAAAGCCACCATGGCTGGGTAAATGATCCAACTTCAGCAATCAATTTACAGTTAAACGAGCTTGTTGAGC
ATATAGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAAGATAATAAGCTGATCGCCCAAATCGATGAATACCTC
GATGACACGTTTATGTTGTTCAGCAGCTACGGCATTAACACAGAAGACTTACAGAAATGGCGTAAATCAGGGAATCGCTT
GTTTCGCTGTTTCCTCAATGTGAGCAGGGCTAACCCCGTTAGCCTCTCCTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References