Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1907202..1907968 Replicon chromosome
Accession NZ_CP019113
Organism Enterobacter sp. SA187

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag BMF08_RS09105 Protein ID WP_072570563.1
Coordinates 1907202..1907693 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag BMF08_RS09110 Protein ID WP_199775952.1
Coordinates 1907681..1907968 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF08_RS09090 1903686..1904387 - 702 WP_072570558.1 thiamine ABC transporter ATP-binding protein ThiQ -
BMF08_RS09095 1904371..1905972 - 1602 WP_072570560.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
BMF08_RS09100 1905948..1906931 - 984 WP_072570561.1 thiamine ABC transporter substrate binding subunit -
BMF08_RS09105 1907202..1907693 - 492 WP_072570563.1 GNAT family N-acetyltransferase Toxin
BMF08_RS09110 1907681..1907968 - 288 WP_199775952.1 DUF1778 domain-containing protein Antitoxin
BMF08_RS09115 1908416..1908850 + 435 WP_072570566.1 hypothetical protein -
BMF08_RS09120 1909093..1909662 + 570 WP_072570567.1 DUF4142 domain-containing protein -
BMF08_RS09125 1909703..1911364 - 1662 WP_072570569.1 HTH-type transcriptional regulator SgrR -
BMF08_RS09130 1911562..1912740 + 1179 WP_072570571.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(5-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17752.49 Da        Isoelectric Point: 9.5590

>T71737 WP_072570563.1 NZ_CP019113:c1907693-1907202 [Enterobacter sp. SA187]
VGKVTAPQPLNSSHILSEFHCGEAVLDEWIRHRGLKNHSTGAARTFVVCRGKTSQVVGFYSLATGSVTHAIAPGSLRRNM
PEPIPVIILARLAVDASYHGKGLGADLLHDAVLRIYRVAENIGVRAIMVHALSDAAKNFYLHHGFVVSNTQENTLFLRLP
EIL

Download         Length: 492 bp

>T71737 NZ_CP019113:c1907693-1907202 [Enterobacter sp. SA187]
GTGGGAAAAGTAACAGCTCCGCAACCGCTTAACTCTTCACATATTCTTTCTGAGTTTCATTGTGGGGAAGCAGTACTGGA
TGAATGGATCAGGCACCGGGGATTAAAAAATCACTCCACCGGTGCGGCCAGAACATTTGTGGTATGCAGGGGAAAGACGT
CACAGGTGGTTGGATTTTACTCCCTGGCTACCGGCAGCGTGACTCACGCCATTGCACCCGGCAGTTTACGACGAAACATG
CCTGAGCCTATTCCTGTCATTATCCTGGCACGTCTTGCAGTCGATGCGAGTTACCACGGCAAAGGTCTGGGCGCGGATTT
ACTTCATGATGCCGTTTTACGCATTTATCGTGTGGCTGAGAATATAGGTGTGCGCGCAATTATGGTTCATGCCCTCTCTG
ACGCGGCGAAAAACTTCTACCTGCATCATGGCTTTGTAGTTTCGAATACGCAGGAAAATACACTTTTCCTACGCTTACCC
GAAATCCTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10783.33 Da        Isoelectric Point: 5.0773

>AT71737 WP_199775952.1 NZ_CP019113:c1907968-1907681 [Enterobacter sp. SA187]
MLYNGANMKSDVQLNIRAKEAQRALIDTAASILHKSRTDFILETACQAAENVILDRRMYNLNDEQYAEFITMLDAPVTAN
PALDTLLARKPQWEK

Download         Length: 288 bp

>AT71737 NZ_CP019113:c1907968-1907681 [Enterobacter sp. SA187]
TTGCTATACAACGGAGCCAACATGAAATCAGATGTCCAGCTCAATATCAGGGCTAAAGAAGCGCAGAGAGCACTTATCGA
TACTGCCGCCAGTATTCTTCATAAATCACGGACTGATTTTATACTTGAGACAGCCTGTCAGGCCGCTGAAAACGTCATCC
TTGATCGTCGAATGTACAATCTCAATGATGAGCAGTATGCCGAATTTATCACTATGCTGGACGCCCCGGTTACCGCTAAT
CCGGCGCTGGATACACTGCTGGCGAGAAAACCGCAGTGGGAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References