Detailed information of TA system TA071734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1225758..1226395
• Replicon: chromosome
• Accession: NZ_CP019113
• Organism: Enterobacter sp. SA187

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BMF08_RS05945
• Protein ID: WP_072571365.1
• Coordinates: 1225758..1225940 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BMF08_RS05950
• Protein ID: WP_072571364.1
• Coordinates: 1225988..1226395 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BMF08_RS05935	1221058..1223661	+	2604	WP_072571367.1	alpha-mannosidase	-
BMF08_RS05940	1223658..1225673	+	2016	WP_072571366.1	metallophosphoesterase	-
BMF08_RS05945	1225758..1225940	+	183	WP_072571365.1	type II toxin-antitoxin system HicA family toxin	Toxin
BMF08_RS05950	1225988..1226395	+	408	WP_072571364.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BMF08_RS05955	1226451..1226765	-	315	WP_072571363.1	L-rhamnose mutarotase	-
BMF08_RS05960	1226762..1227910	-	1149	WP_072571362.1	lactaldehyde reductase	-
BMF08_RS05965	1228010..1229014	-	1005	WP_072571361.1	ABC transporter permease	-
BMF08_RS05970	1229011..1230015	-	1005	WP_072571360.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6763.89 Da
• Isoelectric Point: 10.2535

>T71734 WP_072571365.1 NZ_CP019113:1225758-1225940 [Enterobacter sp. SA187]
MTSAEVMKKLKKAGWEHVRTRGSHHIFEKEGEPEPIVVPHPNKDLAAGTLHKILKQLGEK

Nucleotide

• Length: 183 bp

>T71734 NZ_CP019113:1225758-1225940 [Enterobacter sp. SA187]
ATGACGAGCGCTGAAGTCATGAAGAAGCTGAAAAAGGCAGGTTGGGAGCATGTCCGCACCAGAGGTTCGCATCACATTTT
TGAAAAGGAAGGTGAGCCTGAGCCGATAGTGGTTCCCCATCCAAATAAGGATTTAGCTGCCGGTACGTTACATAAGATTT
TGAAGCAATTAGGCGAAAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15085.88 Da
• Isoelectric Point: 4.9427

>AT71734 WP_072571364.1 NZ_CP019113:1225988-1226395 [Enterobacter sp. SA187]
MKYPVYLHQTESGAFSGFVPDLAGCYFAGDTIDDAIADAHAAIDAYLDYRSEKGKDVPVARTMNDHKDDEDCQGGMWGIV
DIDTSKYDGKSVKLNITLPQNLLRRIDAYVVNNKDYTSRSGFIAELARRELSKRL

Nucleotide

• Length: 408 bp

>AT71734 NZ_CP019113:1225988-1226395 [Enterobacter sp. SA187]
ATGAAATATCCAGTTTATTTACATCAGACCGAAAGCGGCGCTTTTTCTGGTTTTGTGCCCGATCTGGCTGGATGCTATTT
CGCAGGTGATACCATTGATGATGCGATCGCTGATGCTCATGCAGCTATTGATGCGTATCTGGACTACCGGAGTGAGAAAG
GAAAAGACGTACCTGTAGCACGTACGATGAACGATCATAAAGATGATGAAGACTGCCAGGGCGGCATGTGGGGGATCGTG
GATATTGATACCTCTAAATACGATGGCAAATCGGTGAAATTAAATATTACTTTGCCGCAAAATTTGTTAAGAAGAATAGA
TGCTTATGTCGTAAATAATAAAGACTACACCAGCCGTAGCGGTTTTATCGCTGAGCTGGCGAGAAGGGAATTATCAAAAC
GCCTTTAA