Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1200060..1200579 Replicon chromosome
Accession NZ_CP019113
Organism Enterobacter sp. SA187

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag BMF08_RS05845 Protein ID WP_072571387.1
Coordinates 1200060..1200344 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BMF08_RS05850 Protein ID WP_072571386.1
Coordinates 1200337..1200579 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF08_RS05820 1195925..1196953 + 1029 WP_072571392.1 LacI family DNA-binding transcriptional regulator -
BMF08_RS05825 1197171..1197770 + 600 WP_072571391.1 glucose-1-phosphatase -
BMF08_RS05830 1197764..1198636 + 873 WP_072571390.1 virulence factor BrkB family protein -
BMF08_RS05835 1198633..1199070 + 438 WP_072571389.1 D-tyrosyl-tRNA(Tyr) deacylase -
BMF08_RS05840 1199115..1200056 + 942 WP_072571388.1 fatty acid biosynthesis protein FabY -
BMF08_RS05845 1200060..1200344 - 285 WP_072571387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMF08_RS05850 1200337..1200579 - 243 WP_072571386.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BMF08_RS05855 1200801..1201730 - 930 WP_072571385.1 formate dehydrogenase accessory protein FdhE -
BMF08_RS05860 1201727..1202362 - 636 WP_072571384.1 formate dehydrogenase cytochrome b556 subunit -
BMF08_RS05865 1202359..1203261 - 903 WP_072571383.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(4-70)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11162.84 Da        Isoelectric Point: 6.4790

>T71733 WP_072571387.1 NZ_CP019113:c1200344-1200060 [Enterobacter sp. SA187]
MYKLSRLAAEDFGAIYEYSWRQFGPLQADKYTAELDTFLMLLAQNPLMGREINIIEDVRRYDHGQHAIFYQMQNDGIFIA
RILHQQMDPLKHLK

Download         Length: 285 bp

>T71733 NZ_CP019113:c1200344-1200060 [Enterobacter sp. SA187]
ATGTATAAACTCTCCAGGCTGGCCGCCGAGGATTTTGGTGCGATTTATGAATATTCCTGGCGTCAATTTGGCCCATTGCA
GGCAGATAAATACACCGCTGAACTGGATACGTTTCTAATGCTACTCGCTCAAAACCCTTTGATGGGGCGCGAGATAAATA
TTATTGAAGATGTTCGTCGCTACGATCACGGTCAGCACGCCATTTTTTATCAGATGCAGAATGACGGGATTTTTATTGCC
CGCATTCTGCATCAACAAATGGACCCTTTAAAGCATCTGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8995.20 Da        Isoelectric Point: 7.2048

>AT71733 WP_072571386.1 NZ_CP019113:c1200579-1200337 [Enterobacter sp. SA187]
MPRTTSITIGDHLDRFISEMIESGRYGSTSEVVRSALRLLEEQELHNGKLREALEKGLNSGESPLTLQEIATRKKRSLNV

Download         Length: 243 bp

>AT71733 NZ_CP019113:c1200579-1200337 [Enterobacter sp. SA187]
ATGCCCAGAACAACCAGCATAACGATTGGGGACCATTTAGATCGTTTTATTAGCGAGATGATTGAAAGCGGGCGTTATGG
TTCAACAAGCGAAGTCGTGCGTTCCGCGTTACGTTTGCTGGAAGAACAGGAGTTACACAATGGTAAGTTACGCGAAGCGC
TGGAAAAGGGACTTAACAGTGGGGAAAGCCCGTTAACTTTGCAGGAAATTGCGACAAGGAAAAAACGCAGCTTAAATGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References