Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1374874..1375508 Replicon chromosome
Accession NZ_CP019066
Organism Tsukamurella tyrosinosolvens strain MH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ASU32_RS06845 Protein ID WP_202972638.1
Coordinates 1375128..1375508 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ASU32_RS06840 Protein ID WP_068524620.1
Coordinates 1374874..1375092 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASU32_RS06820 1369965..1370513 + 549 WP_102101399.1 thioesterase family protein -
ASU32_RS06825 1370524..1371147 + 624 WP_068524617.1 GNAT family N-acetyltransferase -
ASU32_RS06830 1371150..1374029 + 2880 WP_068741166.1 DEAD/DEAH box helicase -
ASU32_RS06835 1374030..1374815 + 786 WP_102101400.1 hypothetical protein -
ASU32_RS06840 1374874..1375092 + 219 WP_068524620.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ASU32_RS06845 1375128..1375508 + 381 WP_202972638.1 VapC toxin family PIN domain ribonuclease Toxin
ASU32_RS06850 1375587..1376723 + 1137 WP_068524776.1 exonuclease SbcCD subunit D -
ASU32_RS06855 1376720..1379353 + 2634 WP_102101402.1 AAA family ATPase -
ASU32_RS06860 1379444..1379659 + 216 WP_074850442.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13862.71 Da        Isoelectric Point: 4.4016

>T71676 WP_202972638.1 NZ_CP019066:1375128-1375508 [Tsukamurella tyrosinosolvens]
MQRDPELTGQWLEAQLSGAIGSCDPQRAEYRRSARNVDEFDSMSAMFIDLYPDVPVPTTVWSWIDAAQFRLAKVGAARAF
SVVDLLVCATAAARGLVLLHDDADFELAERLLPDVQARRVVGPTAN

Download         Length: 381 bp

>T71676 NZ_CP019066:1375128-1375508 [Tsukamurella tyrosinosolvens]
CTGCAGCGGGACCCTGAGCTGACGGGACAGTGGCTGGAAGCCCAGCTCAGCGGTGCGATCGGTTCGTGCGACCCGCAACG
AGCCGAGTATCGCCGGTCTGCTCGCAACGTCGACGAATTCGACTCGATGAGCGCCATGTTCATCGACCTCTATCCGGATG
TTCCGGTGCCGACGACGGTCTGGAGCTGGATCGACGCTGCGCAGTTCCGTCTCGCGAAGGTCGGCGCGGCGCGCGCGTTC
TCCGTGGTCGACCTGCTCGTCTGCGCGACCGCCGCGGCCCGCGGTCTCGTCCTCCTCCACGACGACGCCGACTTCGAACT
CGCCGAGCGTCTTCTCCCTGATGTGCAGGCGCGACGCGTCGTCGGACCGACGGCGAACTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8241.31 Da        Isoelectric Point: 5.1212

>AT71676 WP_068524620.1 NZ_CP019066:1374874-1375092 [Tsukamurella tyrosinosolvens]
MSVTQIDLDDEALAEVMRLAGVRTKKEAVNLALSDYVDRFRRVEALARSREQAKTWDYDGWIAARADEKAVR

Download         Length: 219 bp

>AT71676 NZ_CP019066:1374874-1375092 [Tsukamurella tyrosinosolvens]
ATGTCAGTCACACAGATCGACCTCGATGACGAGGCGCTGGCCGAGGTCATGCGACTGGCGGGTGTCCGCACCAAGAAGGA
GGCGGTGAACCTCGCGCTGAGCGACTACGTCGACCGGTTTCGCCGCGTCGAAGCGCTTGCGCGCTCGCGTGAGCAGGCGA
AAACGTGGGACTACGACGGGTGGATCGCAGCACGTGCCGACGAGAAGGCGGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References