Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/ElaA-DUF1778
Location 216846..217582 Replicon plasmid unnamed2
Accession NZ_CP019064
Organism Rahnella sp. ERMR1:05

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag BV494_RS24960 Protein ID WP_104925469.1
Coordinates 217103..217582 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag BV494_RS24955 Protein ID WP_104925468.1
Coordinates 216846..217106 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV494_RS24930 212130..213887 + 1758 WP_192938231.1 lipid A ABC transporter ATP-binding protein/permease MsbA -
BV494_RS24935 214361..214717 + 357 WP_104925467.1 transposase -
BV494_RS24940 214637..215787 - 1151 Protein_199 IS30 family transposase -
BV494_RS24945 215855..216121 - 267 Protein_200 transposase -
BV494_RS24950 216195..216398 - 204 Protein_201 hypothetical protein -
BV494_RS24955 216846..217106 + 261 WP_104925468.1 DUF1778 domain-containing protein Antitoxin
BV494_RS24960 217103..217582 + 480 WP_104925469.1 GNAT family N-acetyltransferase Toxin
BV494_RS24965 217673..218721 - 1049 Protein_204 tyrosine-type recombinase/integrase -
BV494_RS24970 219230..219439 - 210 WP_104925470.1 autotransporter outer membrane beta-barrel domain-containing protein -
BV494_RS26005 219436..219540 - 105 WP_192938232.1 autotransporter outer membrane beta-barrel domain-containing protein -
BV494_RS24975 219654..220145 - 492 WP_104925471.1 helix-turn-helix transcriptional regulator -
BV494_RS24980 220742..221575 + 834 WP_104925472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..229977 229977
- flank IS/Tn - - 214637..215650 1013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(26-147)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17178.80 Da        Isoelectric Point: 8.9483

>T71675 WP_104925469.1 NZ_CP019064:217103-217582 [Rahnella sp. ERMR1:05]
MSLQLSAPEPLTTAHILDAFGCGESTLDEWLKRRALTNHLNGASRTFVVATNDKSVVGYYALAAGAVSHREATGAARRNM
PDPVPVIVLGRLAVDLRAQGIKLGASLLQDAVLRVHSIAENTGVRALLVHALHEPAKQFYEHYGFTSSPINPMTLMLRL

Download         Length: 480 bp

>T71675 NZ_CP019064:217103-217582 [Rahnella sp. ERMR1:05]
ATGAGTTTACAATTATCTGCCCCTGAGCCACTCACAACTGCACATATCCTTGATGCTTTTGGTTGTGGGGAATCAACGTT
AGATGAATGGTTAAAACGGCGCGCTCTGACAAACCATTTAAATGGTGCAAGTCGTACTTTTGTTGTCGCGACTAACGATA
AAAGTGTTGTCGGTTATTACGCCCTTGCAGCCGGCGCTGTGTCCCACAGGGAAGCAACAGGGGCAGCTCGGCGTAATATG
CCTGACCCAGTTCCGGTCATTGTATTGGGAAGATTGGCGGTCGACCTTCGCGCTCAGGGAATAAAGTTAGGAGCCTCATT
GTTACAGGATGCTGTTCTTCGAGTTCACTCAATTGCTGAAAATACAGGGGTCAGAGCATTGCTCGTACATGCACTTCATG
AACCAGCTAAACAATTTTATGAACACTACGGTTTTACATCATCGCCAATTAATCCGATGACATTAATGCTTCGCCTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9757.22 Da        Isoelectric Point: 4.7483

>AT71675 WP_104925468.1 NZ_CP019064:216846-217106 [Rahnella sp. ERMR1:05]
MRDAAINLRALPEQRDLIDQAASLLGKNRSDFMLEVACERAQAILLDQVFFQLDTEKFHEFTAMLDAPQKTNQGLEHLMA
VKAPWA

Download         Length: 261 bp

>AT71675 NZ_CP019064:216846-217106 [Rahnella sp. ERMR1:05]
ATGCGTGACGCTGCAATTAATTTACGTGCTTTGCCGGAACAGCGTGATCTCATCGATCAAGCTGCCAGTTTATTGGGTAA
AAACCGATCTGATTTTATGCTGGAAGTAGCTTGTGAGCGCGCGCAGGCTATTCTGCTCGACCAGGTTTTTTTCCAGTTAG
ATACTGAAAAATTTCATGAATTCACAGCGATGCTTGATGCACCTCAAAAGACAAATCAGGGTCTGGAGCACCTGATGGCA
GTGAAAGCACCTTGGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References