Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 11610..12247 Replicon plasmid unnamed2
Accession NZ_CP019064
Organism Rahnella sp. ERMR1:05

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BV494_RS23975 Protein ID WP_104925317.1
Coordinates 11882..12247 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BV494_RS23970 Protein ID WP_104925316.1
Coordinates 11610..11882 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV494_RS23945 6653..7207 + 555 WP_104925312.1 TetR/AcrR family transcriptional regulator -
BV494_RS23950 7703..8578 - 876 WP_104925313.1 LysR family transcriptional regulator -
BV494_RS23955 8681..9616 + 936 WP_104925314.1 NADP-dependent oxidoreductase -
BV494_RS23960 9640..9891 - 252 Protein_10 transposase -
BV494_RS23965 10119..11482 + 1364 WP_104925315.1 IS3 family transposase -
BV494_RS23970 11610..11882 + 273 WP_104925316.1 antitoxin Antitoxin
BV494_RS23975 11882..12247 + 366 WP_104925317.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BV494_RS25970 12355..12510 + 156 WP_192938233.1 hypothetical protein -
BV494_RS23980 12642..13577 - 936 WP_104925318.1 zinc-binding dehydrogenase -
BV494_RS23985 13880..14284 - 405 WP_104925319.1 TetR/AcrR family transcriptional regulator -
BV494_RS23990 14370..14540 + 171 Protein_17 SDR family NAD(P)-dependent oxidoreductase -
BV494_RS23995 14530..14646 + 117 Protein_18 SDR family oxidoreductase -
BV494_RS24000 15112..16003 - 892 Protein_19 LysR family transcriptional regulator -
BV494_RS24005 16145..17020 + 876 WP_104925320.1 NmrA family NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..229977 229977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13294.23 Da        Isoelectric Point: 5.1401

>T71673 WP_104925317.1 NZ_CP019064:11882-12247 [Rahnella sp. ERMR1:05]
MVKGRIPQRGDIWHFNPNPIAGRELRDKHYCIVITVEELNDALGVAICCPISTNADAARSAGVTVSVTPMDTEAGNIRGV
VLCHQVRALDLNAREATFETVAEDNLLREVIFKLTNLIDPQ

Download         Length: 366 bp

>T71673 NZ_CP019064:11882-12247 [Rahnella sp. ERMR1:05]
ATGGTAAAGGGAAGGATTCCGCAACGTGGAGATATTTGGCACTTTAACCCAAATCCAATAGCCGGGCGTGAGCTCAGGGA
TAAGCATTACTGTATCGTTATCACGGTAGAAGAATTAAACGACGCACTCGGCGTTGCAATATGCTGTCCGATATCAACAA
ATGCTGATGCTGCCAGATCAGCAGGCGTGACCGTATCCGTTACGCCGATGGATACCGAGGCCGGAAATATACGCGGCGTG
GTTCTCTGCCACCAGGTGCGAGCGCTCGATCTAAACGCCCGAGAGGCAACGTTTGAAACTGTTGCTGAAGATAATCTGTT
ACGTGAAGTTATTTTTAAACTCACTAATCTGATTGATCCACAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9816.10 Da        Isoelectric Point: 8.5621

>AT71673 WP_104925316.1 NZ_CP019064:11610-11882 [Rahnella sp. ERMR1:05]
MQTVKLRQQGGAMIVTIPRDYATSAGWTVGTEITVKRQGTELSLSPTTRSPRGAFTIAELLGQIDREEIASLNNSVKEFT
SAAPTGKEYW

Download         Length: 273 bp

>AT71673 NZ_CP019064:11610-11882 [Rahnella sp. ERMR1:05]
ATGCAAACTGTAAAATTGCGCCAACAAGGCGGAGCCATGATCGTGACTATTCCCCGCGATTACGCAACATCGGCAGGCTG
GACTGTAGGTACTGAAATTACTGTAAAACGCCAGGGCACAGAATTAAGCCTCTCGCCAACTACACGCTCCCCGCGCGGCG
CATTTACCATTGCTGAACTGCTAGGCCAGATTGATCGCGAAGAAATAGCATCCCTTAACAATAGCGTGAAAGAATTCACC
AGTGCGGCTCCAACCGGTAAGGAATATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References