Detailed information of TA system TA071669

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4260026..4260792
• Replicon: chromosome
• Accession: NZ_CP019062
• Organism: Rahnella sp. ERMR1:05

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: BV494_RS19700
• Protein ID: WP_104924358.1
• Coordinates: 4260424..4260792 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: BV494_RS19695
• Protein ID: WP_104924357.1
• Coordinates: 4260026..4260361 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV494_RS19665	4255387..4255596	-	210	WP_104924354.1	AlpA family transcriptional regulator	-
BV494_RS19670	4256059..4256784	+	726	WP_104924355.1	hypothetical protein	-
BV494_RS19675	4257147..4257902	+	756	WP_104924853.1	50S ribosome-binding GTPase	-
BV494_RS19680	4258150..4258704	+	555	WP_104924356.1	hypothetical protein	-
BV494_RS19685	4258732..4259352	+	621	WP_104924854.1	hypothetical protein	-
BV494_RS19690	4259535..4260014	+	480	WP_004707123.1	DNA repair protein RadC	-
BV494_RS19695	4260026..4260361	+	336	WP_104924357.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BV494_RS19700	4260424..4260792	+	369	WP_104924358.1	TA system toxin CbtA family protein	Toxin
BV494_RS19705	4260920..4261750	+	831	WP_104924855.1	DUF4942 domain-containing protein	-
BV494_RS19710	4261827..4262834	+	1008	WP_104924359.1	restriction endonuclease	-
BV494_RS19715	4263139..4263901	+	763	Protein_3825	integrase arm-type DNA-binding domain-containing protein	-
BV494_RS19720	4263913..4265023	-	1111	Protein_3826	IS3 family transposase	-
BV494_RS19725	4265098..4265250	+	153	Protein_3827	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4255387..4267444	12057

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13673.68 Da
• Isoelectric Point: 6.2158

>T71669 WP_104924358.1 NZ_CP019062:4260424-4260792 [Rahnella sp. ERMR1:05]
MQTLPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMARMGYQTITSVIRGEKQA

Nucleotide

• Length: 369 bp

>T71669 NZ_CP019062:4260424-4260792 [Rahnella sp. ERMR1:05]
ATGCAGACCTTACCTGTCACCCCGAAACGGGCGGCTTACGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTTAC
GTATCTGCTGGAACAGCATTACGGATTGGCGCTTAACGATACCGAGTTCAGTGATGACGCGGTGATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTGGAAAAGTTCGACCTGGTTCGCATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCACCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACTGGCCTGATGGCCCGTAT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGCGAAAAGCAGGCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12498.17 Da
• Isoelectric Point: 6.6328

>AT71669 WP_104924357.1 NZ_CP019062:4260026-4260361 [Rahnella sp. ERMR1:05]
MPSIITSAWGLKRNFTPQFGARLVQEGDRLHFLADRADIRGTFSDAQVRDLDDAFPKFINHLELMLLSGELNPRYQHCVT
LYHKGLTCEADSLGSHGYVYLAIYPTPQSTA

Nucleotide

• Length: 336 bp

>AT71669 NZ_CP019062:4260026-4260361 [Rahnella sp. ERMR1:05]
ATGCCATCAATCATTACCTCAGCCTGGGGACTTAAACGCAACTTTACTCCGCAGTTTGGTGCCCGCTTGGTACAGGAAGG
CGACCGGCTGCATTTTTTGGCTGACCGTGCCGATATTAGAGGGACCTTCAGTGATGCGCAGGTACGTGATTTAGATGACG
CCTTCCCGAAGTTCATCAACCATCTGGAACTGATGCTGCTCTCCGGTGAACTCAATCCCCGTTATCAACACTGCGTCACG
CTTTACCACAAGGGACTAACCTGTGAAGCCGATAGTCTGGGTTCACACGGCTATGTGTATCTCGCCATTTATCCTACACC
CCAATCCACTGCATAA