Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 50869..51245 Replicon plasmid p1540-4
Accession NZ_CP019055
Organism Escherichia coli strain CRE1540

Toxin (Protein)


Gene name parE Uniprot ID A0A075MDK3
Locus tag BVL39_RS27970 Protein ID WP_000969988.1
Coordinates 51063..51245 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BVL39_RS27965 Protein ID WP_001324224.1
Coordinates 50869..51066 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVL39_RS29095 46129..46365 + 237 WP_001323890.1 colicin V immunity protein -
BVL39_RS27950 46343..46654 + 312 WP_001259758.1 colicin V -
BVL39_RS27955 46824..48938 - 2115 WP_001183604.1 peptidase domain-containing ABC transporter -
BVL39_RS27960 48913..50187 - 1275 WP_171961401.1 HlyD family secretion protein -
BVL39_RS27965 50869..51066 + 198 WP_001324224.1 toxin-antitoxin system protein Antitoxin
BVL39_RS27970 51063..51245 + 183 WP_000969988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVL39_RS27975 51344..51652 + 309 WP_000377483.1 hypothetical protein -
BVL39_RS27985 52212..53246 + 1035 WP_072647540.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..184166 184166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6931.07 Da        Isoelectric Point: 4.5349

>T71640 WP_000969988.1 NZ_CP019055:51063-51245 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Download         Length: 183 bp

>T71640 NZ_CP019055:51063-51245 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7658.53 Da        Isoelectric Point: 7.2046

>AT71640 WP_001324224.1 NZ_CP019055:50869-51066 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Download         Length: 198 bp

>AT71640 NZ_CP019055:50869-51066 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075MDK3

Antitoxin

Source ID Structure

References