71607

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 119762..120284 Replicon plasmid pRJA166a
Accession NZ_CP019048
Organism Klebsiella pneumoniae subsp. pneumoniae strain RJA166

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag RJA_RS27125 Protein ID WP_014839901.1
Coordinates 120000..120284 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag RJA_RS27120 Protein ID WP_014839900.1
Coordinates 119762..120010 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJA_RS27085 114940..115296 + 357 WP_017901071.1 hypothetical protein -
RJA_RS27090 115670..116068 + 399 WP_014839899.1 H-NS histone family protein -
RJA_RS27095 116205..116813 + 609 WP_024266306.1 DUF2913 family protein -
RJA_RS27105 117357..117989 + 633 WP_001567369.1 hypothetical protein -
RJA_RS27110 118018..119421 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
RJA_RS27120 119762..120010 + 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RJA_RS27125 120000..120284 + 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RJA_RS27130 120475..120951 + 477 WP_042934526.1 hypothetical protein -
RJA_RS27135 120957..121634 + 678 WP_042934501.1 hypothetical protein -
RJA_RS27140 121651..122370 - 720 WP_042934502.1 cation:proton antiporter -
RJA_RS27145 122611..123213 - 603 WP_014839902.1 hypothetical protein -
RJA_RS27150 123210..123731 - 522 WP_048336588.1 hypothetical protein -
RJA_RS27155 123812..124756 - 945 WP_014839903.1 DsbA family protein -
RJA_RS29935 124819..125028 - 210 WP_125316032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / qnrB4 / blaDHA-1 / sul1 - 1..230606 230606
- flank IS/Tn - - 118018..119421 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T71607 WP_014839901.1 NZ_CP019048:120000-120284 [Klebsiella pneumoniae subsp. pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T71607 NZ_CP019048:120000-120284 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT71607 WP_014839900.1 NZ_CP019048:119762-120010 [Klebsiella pneumoniae subsp. pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT71607 NZ_CP019048:119762-120010 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References