71605

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4800622..4801138 Replicon chromosome
Accession NZ_CP019047
Organism Klebsiella pneumoniae subsp. pneumoniae strain RJA166

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag RJA_RS23695 Protein ID WP_004178374.1
Coordinates 4800622..4800906 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag RJA_RS23700 Protein ID WP_002886901.1
Coordinates 4800896..4801138 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJA_RS23675 4796018..4796326 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
RJA_RS30525 4796411..4796584 + 174 WP_041169004.1 hypothetical protein -
RJA_RS23680 4796587..4797330 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
RJA_RS23685 4797687..4799825 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
RJA_RS23690 4800154..4800618 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
RJA_RS23695 4800622..4800906 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RJA_RS23700 4800896..4801138 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RJA_RS23705 4801216..4803126 - 1911 WP_012737231.1 BglG family transcription antiterminator -
RJA_RS23710 4803149..4804303 - 1155 WP_012737230.1 lactonase family protein -
RJA_RS23715 4804370..4805110 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T71605 WP_004178374.1 NZ_CP019047:c4800906-4800622 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T71605 NZ_CP019047:c4800906-4800622 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT71605 WP_002886901.1 NZ_CP019047:c4801138-4800896 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT71605 NZ_CP019047:c4801138-4800896 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References