Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1994057..1995693 Replicon chromosome
Accession NZ_CP019041
Organism Acinetobacter junii strain 65

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BVL33_RS09735 Protein ID WP_075696499.1
Coordinates 1994362..1995693 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BVL33_RS09730 Protein ID WP_004954417.1
Coordinates 1994057..1994365 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVL33_RS09710 1990481..1991218 - 738 WP_075696497.1 hypothetical protein -
BVL33_RS09715 1991250..1992302 - 1053 WP_075696498.1 hypothetical protein -
BVL33_RS09720 1992951..1993187 + 237 WP_004961824.1 VF530 family protein -
BVL33_RS09725 1993310..1993984 - 675 WP_004961827.1 HEPN domain-containing protein -
BVL33_RS09730 1994057..1994365 - 309 WP_004954417.1 helix-turn-helix domain-containing protein Antitoxin
BVL33_RS09735 1994362..1995693 - 1332 WP_075696499.1 type II toxin-antitoxin system HipA family toxin Toxin
BVL33_RS09740 1995971..1996669 + 699 WP_075696500.1 DUF1826 domain-containing protein -
BVL33_RS09745 1996729..1997526 - 798 WP_075696501.1 sulfite exporter TauE/SafE family protein -
BVL33_RS09750 1997568..1998062 - 495 WP_004954405.1 flavin reductase -
BVL33_RS09755 1998249..1999277 - 1029 WP_075696502.1 methionine synthase -
BVL33_RS09760 1999301..2000296 - 996 WP_075696503.1 DUF1852 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1932196..2016279 84083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-365)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50722.45 Da        Isoelectric Point: 5.0447

>T71581 WP_075696499.1 NZ_CP019041:c1995693-1994362 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYELEYAIHNLDKQDEHACSLSLPVQILIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRHGLESVYSVLNKASGSHLNHFEVIENLCNLLKSIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSITWGSPYEEGGEYRWEQITQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T71581 NZ_CP019041:c1995693-1994362 [Acinetobacter junii]
ATGAAAAAACTAACAATACAGGCGTTACTTGATCAAAGTTGGTTTGATATTGCTGAACTAACATTATTAGAACCTAAACT
AGGCTCAGCAAGTGCCAGTGAATTAGCTTACGAGTTAGAATACGCAATCCACAATTTGGACAAGCAAGATGAGCATGCCT
GTAGTTTGTCGCTACCTGTACAAATACTAATAAAACATGAATCTAGTTCATGGTTTGGTTTTTTAGATGATATTGTTCCA
TCAGGTGCTGCACGCCGTTATTGGGTGAATTTTCTAGGTCTACAAAGACTAACGCATGCTGAGCAAGATAGTATTTTATT
AGAAAAAGGTGGCATCGCACCCGTAGGCAATTTGAGAATTAAAGAAGCTCTTCCACCAATCAATCCTGAATCAACTCTGC
ATTTACGTTATTTTAGTCAAAGTGATGTTGCTGACCGAAATGTAGATTTTCTTGAATATGCACAGCAAATGGGTGCAATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCTCCTAAATTATTGATTCGTGCTACAAAAGATCAAAATATTTGGATTGA
TACATATCAACAAAACTTTGATCAACCTGATCAACATTATCTAGTTAAGTTCCCTAGAAATAATCGTAGTGAGATCGACT
GTAATATTCTCAGAGCAGAATACTATTACTATCAAGAGCTAAAAGAGTTGGGTTTCAATACCATTGAAACTACAGAAATG
AAGCTGATCGAAGGTGAAAAATATCCATCATTATGGCTACCAAGATTTGATGTTGAATGGCACAACCAAAAATGGCATCG
TCATGGGCTTGAATCTGTCTATTCCGTATTAAATAAAGCTTCGGGTAGCCATCTCAATCACTTTGAAGTGATTGAAAATC
TATGCAATTTACTGAAATCTATTGATTCAGAGTTTGATTCAGAACAATTCGTTTGTGAGTGGTTACAGCGAGATTTACTC
AATATTATTTTTGGTAATTCTGATAATCATGGGCGAAATACTTCATTTCTAAAACAATCTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCTCCAATGAAAGCTGATCCAGAAGTTGTTACAAGATCAATAACTTGGGGAAGTCCTTATGAGGAAG
GAGGAGAATATCGATGGGAGCAAATTACACAAAAGCTTGCACATTTATGCGATCCGAATTTATCTCTAACTACATTGAAA
TCTTTAGCAAGTCATCTTGTTGGGCTAAAACAAAGATTAATAGATAAAGGTGTACCAAAACAAATTATGGAGATGCCAGC
GCTTTCATTTGACTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11692.65 Da        Isoelectric Point: 9.9970

>AT71581 WP_004954417.1 NZ_CP019041:c1994365-1994057 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT71581 NZ_CP019041:c1994365-1994057 [Acinetobacter junii]
ATGAATACAAAAAATCAGACTCAAGATCGTCAACAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATCAC
ATTAGGGCAATTATTGGCGTATTTGCGAAAAAATATTCTTGGTATGTCTCAGGAACAATATGCAAATTTAGTCGGTGTAA
GTCGTAGGACGTTAACTGATATTGAACAAGATAAAGGAAAACTTACGCAATCTGTTTTAGACAAGGTATTTAAACCACTT
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCATATTGTGAGAAAGATCATTAAACCATCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References