Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1678647..1680391 Replicon chromosome
Accession NZ_CP019038
Organism Massilia putida strain 6NM-7

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BVG12_RS09645 Protein ID WP_156895836.1
Coordinates 1679504..1680391 (-) Length 296 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BVG12_RS09640 Protein ID WP_075792206.1
Coordinates 1678647..1679483 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVG12_RS09620 1673838..1675334 - 1497 WP_075792202.1 aldehyde dehydrogenase -
BVG12_RS09625 1675342..1676142 - 801 WP_075792203.1 aspartate dehydrogenase -
BVG12_RS09630 1676153..1677838 - 1686 WP_075792204.1 thiamine pyrophosphate-binding protein -
BVG12_RS09635 1677831..1678634 - 804 WP_075792205.1 SDR family oxidoreductase -
BVG12_RS09640 1678647..1679483 - 837 WP_075792206.1 IclR family transcriptional regulator Antitoxin
BVG12_RS09645 1679504..1680391 - 888 WP_156895836.1 alpha/beta hydrolase Toxin
BVG12_RS09650 1680397..1680936 - 540 WP_075792208.1 cupin domain-containing protein -
BVG12_RS09655 1680954..1681718 - 765 WP_075792209.1 SDR family oxidoreductase -
BVG12_RS09660 1681732..1682571 - 840 WP_075792210.1 ABC transporter permease -
BVG12_RS09665 1682568..1683557 - 990 WP_075792211.1 ABC transporter substrate-binding protein -
BVG12_RS09670 1683595..1684383 - 789 WP_075792212.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-291)

Antitoxin

Transcription regulator IclR, N-terminal

(21-71)


Sequences

Toxin        


Download         Length: 296 a.a.        Molecular weight: 31116.79 Da        Isoelectric Point: 8.4924

>T71577 WP_156895836.1 NZ_CP019038:c1680391-1679504 [Massilia putida]
MNHAIAPEADGLRTALLELDRLFPERTIAVDGGVVCYRELVAGTDAPPAGRQVFVLLHGIGSGAATWLACAQALSRSVPG
ARVIAWNAPGYGKSTMLPGTRPDARAYAARLRQLVRGLGIARFTLVGHSLGALMAAAYAGTWPGSLDKLVLLSPARGYGV
RARLAQGTQVERERLSALGELGIHGMATLRSARLLSAGATPVQRDWVRWNMAQLNPAGYTQAVYLLCGDAIENHAHPAVQ
TVPAKVWCGALDPVTTPDDSCGVARLYGFPFGLIPDAGHACHVEQPEAVAHAILN

Download         Length: 888 bp

>T71577 NZ_CP019038:c1680391-1679504 [Massilia putida]
ATGAACCACGCCATCGCACCGGAAGCGGACGGCCTGCGAACCGCCTTGCTGGAGCTGGACCGGCTGTTCCCGGAACGCAC
CATCGCCGTCGACGGCGGCGTCGTGTGCTACCGCGAGCTGGTCGCCGGTACGGACGCGCCGCCGGCGGGCCGCCAGGTGT
TCGTGCTGCTGCACGGGATCGGTTCCGGTGCCGCGACGTGGCTCGCCTGCGCGCAGGCCTTGTCGCGCAGCGTCCCCGGC
GCCCGGGTGATCGCCTGGAACGCGCCGGGCTACGGCAAGTCGACCATGCTGCCCGGTACCCGTCCCGATGCCCGCGCCTA
TGCGGCGCGCCTGCGCCAACTGGTGCGGGGGCTCGGCATCGCGCGCTTCACCCTGGTCGGCCACTCGCTCGGCGCGCTGA
TGGCGGCGGCGTATGCGGGCACCTGGCCCGGTTCGCTGGACAAGCTGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGTG
CGGGCGCGCCTGGCGCAGGGCACGCAAGTGGAACGCGAGCGCCTGTCGGCCCTGGGGGAGCTCGGGATCCACGGTATGGC
CACGCTGCGCTCGGCGCGTCTGCTGTCGGCCGGCGCCACGCCGGTCCAGCGCGATTGGGTGCGCTGGAACATGGCCCAGC
TGAACCCGGCCGGCTACACCCAGGCGGTGTACCTGCTGTGCGGCGACGCGATCGAGAACCATGCGCATCCCGCGGTGCAG
ACCGTGCCGGCTAAGGTGTGGTGCGGCGCGCTCGATCCGGTGACGACACCCGACGACAGCTGCGGCGTGGCGCGCCTGTA
CGGCTTCCCGTTCGGCCTGATCCCGGATGCCGGCCATGCCTGCCACGTGGAGCAGCCGGAAGCGGTCGCCCACGCCATCC
TGAACTGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 31231.66 Da        Isoelectric Point: 6.5066

>AT71577 WP_075792206.1 NZ_CP019038:c1679483-1678647 [Massilia putida]
MNNKPEQADDDGADKYTVPGLERGLRLLCEFSRHEQNLSAPELAKRLDVPRSTVFRLLTTLERMGFVERNPGGRDYRLGM
AVLRLGFEYLASLELTEIGRPLLERLRDEIHYSTNLVVRDGRSIIYVAKSTMAAPFTSTVNVGTRLPVHATVLGRVLLMD
MTLPQLRELYPEEHLKSYTDNTPQTVLDLFNLVQRDRERGYVLEEGFFERGISTVAAPVRDHSGKVVAALGATIPEPRIA
ADKLDDVVARVRGTADELSRLLDHTPAQGAQVVNLWQR

Download         Length: 837 bp

>AT71577 NZ_CP019038:c1679483-1678647 [Massilia putida]
ATGAACAACAAGCCTGAACAAGCCGACGACGACGGCGCCGACAAATACACCGTGCCCGGACTCGAGCGCGGCCTGCGCCT
GCTGTGCGAATTCAGCCGGCACGAACAGAATCTGTCGGCCCCGGAGCTGGCCAAGCGCCTGGATGTGCCGCGTTCCACCG
TGTTCCGCCTCCTGACCACGCTGGAGCGGATGGGCTTCGTCGAGCGCAATCCGGGCGGCCGCGACTATCGCCTCGGCATG
GCCGTGCTGCGTCTCGGCTTCGAATACCTGGCCTCGCTGGAGTTGACCGAGATCGGCCGGCCGCTGCTAGAGCGCCTGCG
CGACGAGATCCATTACTCGACCAACCTGGTGGTGCGCGACGGCCGCTCGATCATCTACGTGGCCAAGTCGACGATGGCGG
CGCCGTTCACCAGCACCGTCAACGTCGGCACCCGCCTGCCGGTGCATGCGACCGTGCTGGGCCGCGTACTGCTGATGGAC
ATGACCCTGCCGCAACTGCGCGAGCTGTATCCGGAAGAGCACCTGAAGTCCTACACCGACAACACCCCGCAGACCGTGCT
GGACCTGTTCAACCTGGTGCAGCGCGACCGCGAGCGCGGCTATGTGCTCGAAGAAGGCTTCTTCGAGCGCGGCATTTCGA
CCGTGGCGGCCCCGGTGCGCGACCACAGCGGCAAGGTGGTGGCGGCCCTCGGTGCCACGATTCCCGAACCGCGCATCGCC
GCCGACAAGCTCGACGACGTGGTGGCCCGGGTGCGCGGCACGGCCGACGAGCTCTCGCGCCTGCTGGATCACACGCCGGC
GCAGGGCGCCCAGGTCGTCAACCTGTGGCAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References