Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4114978..4115813 Replicon chromosome
Accession NZ_CP019029
Organism Escherichia coli strain Ecol_881

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag BE930_RS23455 Protein ID WP_001564063.1
Coordinates 4114978..4115355 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A1AEL8
Locus tag BE930_RS23460 Protein ID WP_038432125.1
Coordinates 4115445..4115813 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE930_RS23430 4110106..4111254 - 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -
BE930_RS23435 4111326..4112309 - 984 WP_001361242.1 KpsF/GutQ family sugar-phosphate isomerase -
BE930_RS23440 4113120..4113290 - 171 Protein_3895 IS110 family transposase -
BE930_RS23445 4113632..4114474 - 843 Protein_3896 DUF4942 domain-containing protein -
BE930_RS29580 4114559..4114753 - 195 WP_024181941.1 DUF957 domain-containing protein -
BE930_RS29585 4114832..4114981 - 150 Protein_3898 hypothetical protein -
BE930_RS23455 4114978..4115355 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
BE930_RS23460 4115445..4115813 - 369 WP_038432125.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE930_RS23470 4115976..4116197 - 222 WP_000692345.1 DUF987 domain-containing protein -
BE930_RS23475 4116262..4116738 - 477 WP_021553055.1 RadC family protein -
BE930_RS23480 4116754..4117233 - 480 WP_001564060.1 antirestriction protein -
BE930_RS23485 4117499..4118317 - 819 WP_001175165.1 DUF945 domain-containing protein -
BE930_RS23490 4118407..4118640 - 234 WP_001278293.1 DUF905 family protein -
BE930_RS23495 4118646..4119323 - 678 WP_001564058.1 hypothetical protein -
BE930_RS23500 4119474..4120154 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papX 3990085..4175404 185319
- flank IS/Tn - - 4113120..4113224 104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T71568 WP_001564063.1 NZ_CP019029:c4115355-4114978 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T71568 NZ_CP019029:c4115355-4114978 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13569.31 Da        Isoelectric Point: 7.0369

>AT71568 WP_038432125.1 NZ_CP019029:c4115813-4115445 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT71568 NZ_CP019029:c4115813-4115445 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEL8

References