Detailed information of TA system TA071561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2460301..2461115
• Replicon: chromosome
• Accession: NZ_CP019029
• Organism: Escherichia coli strain Ecol_881

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: BE930_RS14970
• Protein ID: WP_001054376.1
• Coordinates: 2460301..2460558 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: BE930_RS14975
• Protein ID: WP_001309181.1
• Coordinates: 2460570..2461115 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE930_RS14930	2455561..2456541	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
BE930_RS14945	2457156..2458136	-	981	WP_000019400.1	IS5-like element IS5 family transposase	-
BE930_RS14955	2458323..2459563	-	1241	Protein_2349	helicase YjhR	-
BE930_RS29460	2459679..2459924	+	246	Protein_2350	GNAT family N-acetyltransferase	-
BE930_RS14970	2460301..2460558	+	258	WP_001054376.1	hypothetical protein	Toxin
BE930_RS14975	2460570..2461115	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
BE930_RS14980	2461171..2461917	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
BE930_RS14985	2462086..2462304	+	219	Protein_2354	hypothetical protein	-
BE930_RS29825	2462342..2462458	+	117	Protein_2355	VOC family protein	-
BE930_RS14995	2462703..2463824	+	1122	WP_000010829.1	M42 family metallopeptidase	-
BE930_RS15000	2463821..2464099	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BE930_RS15005	2464111..2465424	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB	2449186..2461115	11929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T71561 WP_001054376.1 NZ_CP019029:2460301-2460558 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T71561 NZ_CP019029:2460301-2460558 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT71561 WP_001309181.1 NZ_CP019029:2460570-2461115 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT71561 NZ_CP019029:2460570-2461115 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8