Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 2271452..2272002 | Replicon | chromosome |
Accession | NZ_CP019029 | ||
Organism | Escherichia coli strain Ecol_881 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | BE930_RS14020 | Protein ID | WP_001160966.1 |
Coordinates | 2271452..2271766 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1NMQ0 |
Locus tag | BE930_RS14025 | Protein ID | WP_000125568.1 |
Coordinates | 2271769..2272002 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BE930_RS13995 | 2267127..2268413 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
BE930_RS14000 | 2268413..2269402 | + | 990 | WP_000241224.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
BE930_RS14005 | 2269399..2270220 | + | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
BE930_RS14010 | 2270223..2270600 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
BE930_RS14015 | 2270607..2271455 | + | 849 | WP_000257195.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
BE930_RS14020 | 2271452..2271766 | - | 315 | WP_001160966.1 | CcdB family protein | Toxin |
BE930_RS14025 | 2271769..2272002 | - | 234 | WP_000125568.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
BE930_RS14030 | 2272088..2272567 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
BE930_RS14035 | 2272759..2274621 | - | 1863 | WP_022645165.1 | glutathione-regulated potassium-efflux system protein KefC | - |
BE930_RS14040 | 2274614..2275144 | - | 531 | WP_000600732.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
BE930_RS14045 | 2275252..2276583 | - | 1332 | WP_001183201.1 | MFS transporter | - |
BE930_RS14050 | 2276641..2276928 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T71556 WP_001160966.1 NZ_CP019029:c2271766-2271452 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T71556 NZ_CP019029:c2271766-2271452 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8560.55 Da Isoelectric Point: 5.8062
>AT71556 WP_000125568.1 NZ_CP019029:c2272002-2271769 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT71556 NZ_CP019029:c2272002-2271769 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEF2 |