Detailed information of TA system TA071552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 1411009..1411714
• Replicon: chromosome
• Accession: NZ_CP019029
• Organism: Escherichia coli strain Ecol_881

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: BE930_RS09635
• Protein ID: WP_000539521.1
• Coordinates: 1411009..1411395 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BE930_RS09640
• Protein ID: WP_001280945.1
• Coordinates: 1411385..1411714 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE930_RS09615	1407013..1407639	+	627	WP_001295292.1	glutathione S-transferase GstB	-
BE930_RS09620	1407636..1408751	-	1116	WP_000554964.1	aldose sugar dehydrogenase YliI	-
BE930_RS09625	1408862..1409245	-	384	WP_000497137.1	biofilm formation regulator BssR	-
BE930_RS09630	1409458..1410783	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
BE930_RS09635	1411009..1411395	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BE930_RS09640	1411385..1411714	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
BE930_RS09645	1411784..1413112	-	1329	WP_022645414.1	GGDEF domain-containing protein	-
BE930_RS09650	1413120..1415468	-	2349	WP_022645413.1	EAL domain-containing protein	-
BE930_RS09655	1415645..1416556	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T71552 WP_000539521.1 NZ_CP019029:1411009-1411395 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T71552 NZ_CP019029:1411009-1411395 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT71552 WP_001280945.1 NZ_CP019029:1411385-1411714 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT71552 NZ_CP019029:1411385-1411714 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6