Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3213324..3214158 Replicon chromosome
Accession NZ_CP019020
Organism Escherichia coli strain Ecol_244

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag BE937_RS19535 Protein ID WP_000854808.1
Coordinates 3213324..3213701 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag BE937_RS19540 Protein ID WP_001354276.1
Coordinates 3213790..3214158 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE937_RS19495 3208601..3208764 - 164 Protein_3087 tail fiber assembly protein -
BE937_RS19500 3208838..3209452 - 615 WP_001019923.1 YagU family protein -
BE937_RS19505 3209667..3209852 - 186 WP_000146240.1 hypothetical protein -
BE937_RS28580 3209901..3210059 + 159 Protein_3090 integrase -
BE937_RS19515 3210285..3211604 + 1320 WP_000144688.1 site-specific integrase -
BE937_RS19520 3211697..3212545 - 849 WP_078235133.1 DUF4942 domain-containing protein -
BE937_RS19525 3212630..3212827 - 198 WP_029396577.1 DUF957 domain-containing protein -
BE937_RS19530 3212839..3213327 - 489 WP_039022338.1 hypothetical protein -
BE937_RS19535 3213324..3213701 - 378 WP_000854808.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE937_RS19540 3213790..3214158 - 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BE937_RS19545 3214208..3214852 - 645 WP_029396485.1 hypothetical protein -
BE937_RS19550 3214867..3215088 - 222 WP_000692353.1 DUF987 domain-containing protein -
BE937_RS19555 3215157..3215633 - 477 WP_001384029.1 RadC family protein -
BE937_RS19560 3215648..3216133 - 486 WP_000214317.1 antirestriction protein -
BE937_RS19565 3216224..3217042 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3171554..3254678 83124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T71526 WP_000854808.1 NZ_CP019020:c3213701-3213324 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T71526 NZ_CP019020:c3213701-3213324 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT71526 WP_001354276.1 NZ_CP019020:c3214158-3213790 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT71526 NZ_CP019020:c3214158-3213790 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References