Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1340480..1341311 Replicon chromosome
Accession NZ_CP019020
Organism Escherichia coli strain Ecol_244

Toxin (Protein)


Gene name yeeV Uniprot ID A0A768PNB2
Locus tag BE937_RS09340 Protein ID WP_061157912.1
Coordinates 1340480..1340854 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A785EPM7
Locus tag BE937_RS09345 Protein ID WP_001535568.1
Coordinates 1340943..1341311 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE937_RS09305 1335876..1337042 + 1167 WP_061157914.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BE937_RS09310 1337161..1337634 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
BE937_RS09315 1337832..1338890 + 1059 WP_001200890.1 FUSC family protein -
BE937_RS09320 1339062..1339391 + 330 WP_000450409.1 DUF496 family protein -
BE937_RS09325 1339492..1339674 - 183 WP_061157913.1 ethanolamine utilization protein -
BE937_RS09330 1339728..1339874 + 147 Protein_1217 transposase domain-containing protein -
BE937_RS28135 1340163..1340276 - 114 WP_001161660.1 DUF957 domain-containing protein -
BE937_RS09335 1340289..1340483 - 195 WP_000988601.1 hypothetical protein -
BE937_RS09340 1340480..1340854 - 375 WP_061157912.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE937_RS09345 1340943..1341311 - 369 WP_001535568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BE937_RS09350 1341385..1341606 - 222 WP_061157911.1 DUF987 domain-containing protein -
BE937_RS09355 1341669..1342145 - 477 WP_078235017.1 RadC family protein -
BE937_RS09360 1342161..1342640 - 480 WP_061157910.1 antirestriction protein -
BE937_RS09365 1342903..1343724 - 822 WP_001234571.1 DUF945 domain-containing protein -
BE937_RS09375 1343945..1344355 - 411 WP_061157909.1 hypothetical protein -
BE937_RS09380 1344371..1345048 - 678 WP_001362823.1 hypothetical protein -
BE937_RS09385 1345184..1346254 - 1071 WP_061157908.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13871.91 Da        Isoelectric Point: 7.8522

>T71514 WP_061157912.1 NZ_CP019020:c1340854-1340480 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNSITLGKYPEAK

Download         Length: 375 bp

>T71514 NZ_CP019020:c1340854-1340480 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAGCATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13481.26 Da        Isoelectric Point: 5.0468

>AT71514 WP_001535568.1 NZ_CP019020:c1341311-1340943 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT71514 NZ_CP019020:c1341311-1340943 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
CCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCAATCAGCATACCGTCACGCTGTATGCGAAGGGGCTGGCCTGTGAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A768PNB2

Antitoxin

Source ID Structure
AlphaFold DB A0A785EPM7

References