Detailed information of TA system TA071498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 42505..42881
• Replicon: plasmid pEC244_2
• Accession: NZ_CP019018
• Organism: Escherichia coli strain Ecol_244

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: BE937_RS00950
• Protein ID: WP_000969988.1
• Coordinates: 42505..42687 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: BE937_RS00955
• Protein ID: WP_001324224.1
• Coordinates: 42684..42881 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE937_RS00935	40504..41538	-	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-
BE937_RS00945	42098..42406	-	309	WP_000377483.1	hypothetical protein	-
BE937_RS00950	42505..42687	-	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BE937_RS00955	42684..42881	-	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
BE937_RS00965	43563..44837	+	1275	WP_000489609.1	HlyD family secretion protein	-
BE937_RS00970	44812..46926	+	2115	WP_113987052.1	peptidase domain-containing ABC transporter	-
BE937_RS00975	47096..47407	-	312	WP_001259758.1	colicin V	-
BE937_RS28005	47385..47621	-	237	WP_001323890.1	colicin V immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA	1..158911	158911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T71498 WP_000969988.1 NZ_CP019018:c42687-42505 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T71498 NZ_CP019018:c42687-42505 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT71498 WP_001324224.1 NZ_CP019018:c42881-42684 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT71498 NZ_CP019018:c42881-42684 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A075MDK3