Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3834976..3835807 Replicon chromosome
Accession NZ_CP019015
Organism Escherichia coli strain Ecol_AZ162

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag BE965_RS20940 Protein ID WP_000854815.1
Coordinates 3834976..3835350 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag BE965_RS20945 Protein ID WP_001280918.1
Coordinates 3835439..3835807 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE965_RS20905 3831018..3831347 + 330 WP_000450409.1 DUF496 family protein -
BE965_RS20910 3831520..3833133 - 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
BE965_RS20915 3833164..3833514 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
BE965_RS20920 3833511..3833936 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
BE965_RS20925 3834018..3834170 - 153 WP_050482493.1 ethanolamine utilization protein -
BE965_RS20930 3834224..3834370 + 147 Protein_3549 transposase domain-containing protein -
BE965_RS28435 3834659..3834772 - 114 WP_001161660.1 DUF957 domain-containing protein -
BE965_RS20935 3834785..3834979 - 195 WP_000988600.1 hypothetical protein -
BE965_RS20940 3834976..3835350 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
BE965_RS20945 3835439..3835807 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE965_RS20950 3835823..3836467 - 645 WP_000086752.1 hypothetical protein -
BE965_RS20955 3836486..3836707 - 222 WP_000692345.1 DUF987 domain-containing protein -
BE965_RS20960 3836770..3837246 - 477 WP_001186775.1 RadC family protein -
BE965_RS20965 3837262..3837735 - 474 WP_001350782.1 antirestriction protein -
BE965_RS20975 3838077..3838895 - 819 WP_022645069.1 DUF945 domain-containing protein -
BE965_RS20985 3839116..3839526 - 411 WP_000846703.1 hypothetical protein -
BE965_RS20990 3839542..3839892 - 351 Protein_3560 hypothetical protein -
BE965_RS20995 3839975..3840721 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T71484 WP_000854815.1 NZ_CP019015:c3835350-3834976 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T71484 NZ_CP019015:c3835350-3834976 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT71484 WP_001280918.1 NZ_CP019015:c3835807-3835439 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT71484 NZ_CP019015:c3835807-3835439 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References