Detailed information of TA system TA071472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1072078..1072898
• Replicon: chromosome
• Accession: NZ_CP019015
• Organism: Escherichia coli strain Ecol_AZ162

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: BE965_RS07020
• Protein ID: WP_001054379.1
• Coordinates: 1072078..1072335 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: BE965_RS07025
• Protein ID: WP_000123957.1
• Coordinates: 1072347..1072898 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE965_RS06995	1067625..1068605	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
BE965_RS07005	1069188..1070294	-	1107	Protein_1000	helicase YjhR	-
BE965_RS07010	1070357..1071504	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
BE965_RS07015	1071537..1071701	+	165	Protein_1002	GNAT family N-acetyltransferase	-
BE965_RS07020	1072078..1072335	+	258	WP_001054379.1	YjhX family toxin	Toxin
BE965_RS07025	1072347..1072898	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
BE965_RS07030	1072950..1073696	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
BE965_RS07035	1073824..1074084	+	261	WP_000077645.1	hypothetical protein	-
BE965_RS28910	1074122..1074238	+	117	Protein_1007	VOC family protein	-
BE965_RS07045	1074483..1075604	+	1122	WP_000010833.1	M42 family metallopeptidase	-
BE965_RS07050	1075601..1075879	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BE965_RS07055	1075891..1077204	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	1060699..1081119	20420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T71472 WP_001054379.1 NZ_CP019015:1072078-1072335 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T71472 NZ_CP019015:1072078-1072335 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT71472 WP_000123957.1 NZ_CP019015:1072347-1072898 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT71472 NZ_CP019015:1072347-1072898 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030