Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 68099..68658 | Replicon | plasmid pECAZ162_KPC |
Accession | NZ_CP019014 | ||
Organism | Escherichia coli strain Ecol_AZ162 |
Toxin (Protein)
Gene name | relE | Uniprot ID | V0SVC8 |
Locus tag | BE965_RS01100 | Protein ID | WP_000421272.1 |
Coordinates | 68383..68658 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | V0SRR3 |
Locus tag | BE965_RS01095 | Protein ID | WP_001387467.1 |
Coordinates | 68099..68383 (+) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BE965_RS01065 | 63562..64002 | - | 441 | Protein_71 | zinc-binding dehydrogenase | - |
BE965_RS01070 | 63976..64170 | + | 195 | WP_000796505.1 | hypothetical protein | - |
BE965_RS01075 | 64403..65293 | + | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
BE965_RS01080 | 65318..65698 | + | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
BE965_RS01085 | 65731..66696 | + | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
BE965_RS01090 | 66742..67494 | - | 753 | WP_000562172.1 | IclR family transcriptional regulator | - |
BE965_RS01095 | 68099..68383 | + | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
BE965_RS01100 | 68383..68658 | + | 276 | WP_000421272.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BE965_RS01105 | 68764..69057 | + | 294 | WP_001105060.1 | hypothetical protein | - |
BE965_RS28040 | 69092..69220 | - | 129 | Protein_80 | IS481 family transposase | - |
BE965_RS01110 | 69253..70422 | - | 1170 | WP_001072355.1 | hypothetical protein | - |
BE965_RS01120 | 70915..71222 | + | 308 | Protein_82 | type II toxin-antitoxin system ParD family antitoxin | - |
BE965_RS01135 | 71511..72208 | + | 698 | Protein_83 | IS1 family transposase | - |
BE965_RS01145 | 72462..73484 | - | 1023 | WP_000361402.1 | helicase UvrD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aph(3'')-Ib / aph(6)-Id / blaKPC-3 / tet(A) / sul1 / qacE / aadA5 / sul2 | - | 1..142829 | 142829 | |
- | flank | IS/Tn | - | - | 71705..72208 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 10.0871
>T71459 WP_000421272.1 NZ_CP019014:68383-68658 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T71459 NZ_CP019014:68383-68658 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT71459 WP_001387467.1 NZ_CP019014:68099-68383 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT71459 NZ_CP019014:68099-68383 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0SVC8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0Y880 |