Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 48012..48571 | Replicon | plasmid pECAZ161_1 |
Accession | NZ_CP019011 | ||
Organism | Escherichia coli strain Ecol_AZ161 |
Toxin (Protein)
Gene name | relE | Uniprot ID | U9YB49 |
Locus tag | BE946_RS01490 | Protein ID | WP_000421259.1 |
Coordinates | 48296..48571 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | U9Y625 |
Locus tag | BE946_RS01485 | Protein ID | WP_001178087.1 |
Coordinates | 48012..48296 (+) | Length | 95 a.a. |
Genomic Context
Location: 46235..47113 (879 bp)
Type: Others
Protein ID: WP_000729439.1
Type: Others
Protein ID: WP_000729439.1
Location: 48012..48296 (285 bp)
Type: Antitoxin
Protein ID: WP_001178087.1
Type: Antitoxin
Protein ID: WP_001178087.1
Location: 48296..48571 (276 bp)
Type: Toxin
Protein ID: WP_000421259.1
Type: Toxin
Protein ID: WP_000421259.1
Location: 48677..48952 (276 bp)
Type: Others
Protein ID: WP_001401588.1
Type: Others
Protein ID: WP_001401588.1
Location: 43201..43821 (621 bp)
Type: Others
Protein ID: WP_000176497.1
Type: Others
Protein ID: WP_000176497.1
Location: 44088..44750 (663 bp)
Type: Others
Protein ID: WP_000154141.1
Type: Others
Protein ID: WP_000154141.1
Location: 44891..45532 (642 bp)
Type: Others
Protein ID: WP_000335849.1
Type: Others
Protein ID: WP_000335849.1
Location: 49143..49409 (267 bp)
Type: Others
Protein ID: WP_000627832.1
Type: Others
Protein ID: WP_000627832.1
Location: 49409..49645 (237 bp)
Type: Others
Protein ID: WP_032151844.1
Type: Others
Protein ID: WP_032151844.1
Location: 49655..50257 (603 bp)
Type: Others
Protein ID: WP_000521606.1
Type: Others
Protein ID: WP_000521606.1
Location: 50433..51485 (1053 bp)
Type: Others
Protein ID: WP_000655519.1
Type: Others
Protein ID: WP_000655519.1
Location: 51698..52288 (591 bp)
Type: Others
Protein ID: WP_001401589.1
Type: Others
Protein ID: WP_001401589.1
Location: 52288..52542 (255 bp)
Type: Others
Protein ID: WP_000343106.1
Type: Others
Protein ID: WP_000343106.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BE946_RS01450 | 43201..43821 | - | 621 | WP_000176497.1 | DUF1449 family protein | - |
BE946_RS01460 | 44088..44750 | - | 663 | WP_000154141.1 | hypothetical protein | - |
BE946_RS01465 | 44891..45532 | - | 642 | WP_000335849.1 | transcription termination factor NusG | - |
BE946_RS01475 | 46235..47113 | + | 879 | WP_000729439.1 | incFII family plasmid replication initiator RepA | - |
BE946_RS01485 | 48012..48296 | + | 285 | WP_001178087.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
BE946_RS01490 | 48296..48571 | + | 276 | WP_000421259.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BE946_RS01495 | 48677..48952 | + | 276 | WP_001401588.1 | hypothetical protein | - |
BE946_RS27805 | 49143..49409 | - | 267 | WP_000627832.1 | hypothetical protein | - |
BE946_RS27810 | 49409..49645 | - | 237 | WP_032151844.1 | hypothetical protein | - |
BE946_RS01515 | 49655..50257 | - | 603 | WP_000521606.1 | hypothetical protein | - |
BE946_RS01520 | 50433..51485 | - | 1053 | WP_000655519.1 | hypothetical protein | - |
BE946_RS01525 | 51698..52288 | - | 591 | WP_001401589.1 | hypothetical protein | - |
BE946_RS01530 | 52288..52542 | - | 255 | WP_000343106.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..74891 | 74891 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10736.45 Da Isoelectric Point: 9.9324
>T71433 WP_000421259.1 NZ_CP019011:48296-48571 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T71433 NZ_CP019011:48296-48571 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAAGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAAGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10488.92 Da Isoelectric Point: 5.6558
>AT71433 WP_001178087.1 NZ_CP019011:48012-48296 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT71433 NZ_CP019011:48012-48296 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA