Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 48012..48571 Replicon plasmid pECAZ161_1
Accession NZ_CP019011
Organism Escherichia coli strain Ecol_AZ161

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag BE946_RS01490 Protein ID WP_000421259.1
Coordinates 48296..48571 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag BE946_RS01485 Protein ID WP_001178087.1
Coordinates 48012..48296 (+) Length 95 a.a.

Genomic Context


BE946_RS01475BE946_RS01485BE946_RS01490BE946_RS01495BE946_RS01450BE946_RS01460BE946_RS01465BE946_RS27805BE946_RS27810BE946_RS01515BE946_RS01520BE946_RS01525BE946_RS01530
Location: 46235..47113 (879 bp)
Type: Others
Protein ID: WP_000729439.1
Location: 48012..48296 (285 bp)
Type: Antitoxin
Protein ID: WP_001178087.1
Location: 48296..48571 (276 bp)
Type: Toxin
Protein ID: WP_000421259.1
Location: 48677..48952 (276 bp)
Type: Others
Protein ID: WP_001401588.1
Location: 43201..43821 (621 bp)
Type: Others
Protein ID: WP_000176497.1
Location: 44088..44750 (663 bp)
Type: Others
Protein ID: WP_000154141.1
Location: 44891..45532 (642 bp)
Type: Others
Protein ID: WP_000335849.1
Location: 49143..49409 (267 bp)
Type: Others
Protein ID: WP_000627832.1
Location: 49409..49645 (237 bp)
Type: Others
Protein ID: WP_032151844.1
Location: 49655..50257 (603 bp)
Type: Others
Protein ID: WP_000521606.1
Location: 50433..51485 (1053 bp)
Type: Others
Protein ID: WP_000655519.1
Location: 51698..52288 (591 bp)
Type: Others
Protein ID: WP_001401589.1
Location: 52288..52542 (255 bp)
Type: Others
Protein ID: WP_000343106.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BE946_RS0145043201..43821-621WP_000176497.1DUF1449 family protein-
BE946_RS0146044088..44750-663WP_000154141.1hypothetical protein-
BE946_RS0146544891..45532-642WP_000335849.1transcription termination factor NusG-
BE946_RS0147546235..47113+879WP_000729439.1incFII family plasmid replication initiator RepA-
BE946_RS0148548012..48296+285WP_001178087.1ribbon-helix-helix domain-containing proteinAntitoxin
BE946_RS0149048296..48571+276WP_000421259.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BE946_RS0149548677..48952+276WP_001401588.1hypothetical protein-
BE946_RS2780549143..49409-267WP_000627832.1hypothetical protein-
BE946_RS2781049409..49645-237WP_032151844.1hypothetical protein-
BE946_RS0151549655..50257-603WP_000521606.1hypothetical protein-
BE946_RS0152050433..51485-1053WP_000655519.1hypothetical protein-
BE946_RS0152551698..52288-591WP_001401589.1hypothetical protein-
BE946_RS0153052288..52542-255WP_000343106.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..7489174891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T71433 WP_000421259.1 NZ_CP019011:48296-48571 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T71433 NZ_CP019011:48296-48571 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAAGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT71433 WP_001178087.1 NZ_CP019011:48012-48296 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT71433 NZ_CP019011:48012-48296 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBU9YB49


Antitoxin

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Source
ID
Structure
AlphaFold DBU9Y625

References