Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3115622..3116466 Replicon chromosome
Accession NZ_CP019008
Organism Escherichia coli strain Ecol_AZ159

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag BE939_RS17220 Protein ID WP_000854686.1
Coordinates 3115622..3116005 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag BE939_RS17225 Protein ID WP_001285602.1
Coordinates 3116086..3116466 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE939_RS17180 3110624..3111115 - 492 WP_001309402.1 DUF1097 domain-containing protein -
BE939_RS17185 3111217..3111771 - 555 WP_001001921.1 molecular chaperone YcdY -
BE939_RS17190 3111795..3112532 - 738 WP_000283670.1 zinc-binding phosphatase -
BE939_RS17195 3112587..3113525 - 939 WP_000351279.1 glyoxylate/hydroxypyruvate reductase GhrA -
BE939_RS17205 3113996..3114838 - 843 WP_021513039.1 DUF4942 domain-containing protein -
BE939_RS17210 3114923..3115120 - 198 WP_000839253.1 DUF957 domain-containing protein -
BE939_RS17215 3115137..3115625 - 489 WP_001054233.1 hypothetical protein -
BE939_RS17220 3115622..3116005 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
BE939_RS17225 3116086..3116466 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BE939_RS17230 3116477..3117160 - 684 WP_001696891.1 hypothetical protein -
BE939_RS17235 3117179..3117400 - 222 WP_001696890.1 DUF987 domain-containing protein -
BE939_RS17240 3117463..3117939 - 477 WP_001186726.1 RadC family protein -
BE939_RS17245 3117955..3118440 - 486 WP_001697217.1 antirestriction protein -
BE939_RS17250 3118532..3119350 - 819 WP_001697216.1 DUF945 domain-containing protein -
BE939_RS17260 3119450..3119683 - 234 WP_001119719.1 DUF905 family protein -
BE939_RS17265 3119762..3120216 - 455 Protein_2976 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(B) csgC / csgA / csgB / csgD / csgE / csgF / csgG 3106115..3164310 58195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T71416 WP_000854686.1 NZ_CP019008:c3116005-3115622 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T71416 NZ_CP019008:c3116005-3115622 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT71416 WP_001285602.1 NZ_CP019008:c3116466-3116086 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT71416 NZ_CP019008:c3116466-3116086 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References